Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0096 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 1 | 0.5 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 1 | 0.5 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1468 | 0.1468 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0096 | 1 | 0.5 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Plasmodium falciparum | hexokinase | 0.0096 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0096 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 63.1 nM | Activation of human recombinant glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH assessed as glucose 6-phosphate formation by spectrometric analysis | ChEMBL. | 22459213 |
FC (binding) | = 1.9 | Activation of human recombinant glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH assessed as glucose 6-phosphate formation by spectrometric analysis relative to control | ChEMBL. | 22459213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.