Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1286 | 0.8878 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0994 | 0.5794 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0994 | 0.5794 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0994 | 0.5794 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0994 | 0.5794 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1392 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0994 | 0.5794 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0994 | 0.5794 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1392 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.1131 | 0.7241 | 0.7241 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.1024 | 0.6119 | 0.8166 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0994 | 0.5794 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0994 | 0.5794 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0947 | 0.5304 | 0.5392 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.1131 | 0.7241 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.