Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0041 | 0.162 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0041 | 0.162 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0041 | 0.162 | 1 |
Brugia malayi | Fatty acid elongation protein 3 | 0.0041 | 0.162 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0008 | 0 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0041 | 0.162 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0208 | 1 | 1 |
Trypanosoma brucei | Fatty acid elongase | 0.0041 | 0.162 | 1 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0041 | 0.162 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0041 | 0.162 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0208 | 1 | 1 |
Brugia malayi | GNS1/SUR4 family protein | 0.0041 | 0.162 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0208 | 1 | 1 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0041 | 0.162 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0041 | 0.162 | 1 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0041 | 0.162 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0208 | 1 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0041 | 0.162 | 0.162 |
Leishmania major | fatty acid elongase, putative | 0.0041 | 0.162 | 1 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0041 | 0.162 | 1 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0041 | 0.162 | 0.162 |
Leishmania major | fatty acid elongase, putative | 0.0041 | 0.162 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 86 nM | Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated for 10 mins prior MCH peptide-stimulation measured after 45 mins by IP3-SPA-YSI assay | ChEMBL. | 22497763 |
IC50 (binding) | = 1095 nM | Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay | ChEMBL. | 22497763 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.