Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Mus musculus | retinoid X receptor beta | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Mus musculus | retinoid X receptor gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor gamma | 340 aa | 338 aa | 24.6 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.0802 | 0.8997 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0507 | 0.1003 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.047 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0802 | 0.8997 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0507 | 0.1003 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 189 nM | Effective concentration against retinoid receptor isoform (RXR beta) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 189 nM | Effective concentration against retinoid receptor isoform (RXR beta) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 197 nM | Effective concentration against retinoid receptor isoform (RXR alpha) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 197 nM | Effective concentration against retinoid receptor isoform (RXR alpha) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 337 nM | Effective concentration against retinoid receptor isoform (RAR beta) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 337 nM | Effective concentration against retinoid receptor isoform (RAR beta) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 383 nM | Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 383 nM | Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 397 nM | Effective concentration against retinoid receptor isoform (RAR gamma) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | = 397 nM | Effective concentration against retinoid receptor isoform (RAR gamma) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | > 10000 nM | Effective concentration against retinoid receptor isoform (RAR alpha) expressed in CV-1 cells | ChEMBL. | 8071941 |
EC50 (binding) | > 10000 nM | Effective concentration against retinoid receptor isoform (RAR alpha) expressed in CV-1 cells | ChEMBL. | 8071941 |
Kd (binding) | = 69 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR alpha | ChEMBL. | 8071941 |
Kd (binding) | = 69 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR alpha | ChEMBL. | 8071941 |
Kd (binding) | = 94 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR gamma | ChEMBL. | 8071941 |
Kd (binding) | = 94 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR gamma | ChEMBL. | 8071941 |
Kd (binding) | = 108 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR beta | ChEMBL. | 8071941 |
Kd (binding) | = 108 nM | Inhibition of [3H]-9-cis-RA binding to baculovirus expressed retinoid receptor RXR beta | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR alpha | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR beta | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Tested for binding affinity against [3H]-ATRA binding to retinoid receptor isoform (RAR gamma) expressed in baculovirus | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR alpha | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Inhibition of [3H]-ATRA binding to baculovirus expressed retinoid receptor RAR beta | ChEMBL. | 8071941 |
Kd (binding) | > 1000 nM | Tested for binding affinity against [3H]-ATRA binding to retinoid receptor isoform (RAR gamma) expressed in baculovirus | ChEMBL. | 8071941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.