Detailed information for compound 1642216

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 217.307 | Formula: C14H19NO
  • H donors: 1 H acceptors: 0 LogP: 2.14 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC[C@H]1C[C@@H]1c1ccccc1OCC1CC1
  • InChi: 1S/C14H19NO/c15-8-11-7-13(11)12-3-1-2-4-14(12)16-9-10-5-6-10/h1-4,10-11,13H,5-9,15H2/t11-,13+/m1/s1
  • InChiKey: UXQKEFDSVCUVQW-YPMHNXCESA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax phosphodiesterase gamma, putative 0.0081 0.025 0.3
Echinococcus multilocularis cyclin G2 0.0026 0.0035 0.0035
Entamoeba histolytica hypothetical protein 0.0026 0.0035 0.0638
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0049
Echinococcus multilocularis cyclins 0.0106 0.035 0.035
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0081 0.025 0.025
Entamoeba histolytica cyclin, putative 0.0106 0.035 0.6436
Echinococcus granulosus defective proboscis extension response 0.0031 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0049
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0081 0.0073
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0081 0.025 0.3323
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0081 0.025 0.2083
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0081 0.025 0.0606
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0035 0.0026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.025 0.2341
Echinococcus multilocularis cyclin y 0.0026 0.0035 0.0035
Leishmania major mitotic cyclin, putative 0.0026 0.0035 0.0325
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.025 0.2341
Giardia lamblia Hypothetical protein 0.0081 0.025 0.4225
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0289 0.1068 1
Echinococcus granulosus cyclin A3 4 0.0026 0.0035 0.0035
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0095 0.023
Trichomonas vaginalis cyclin B, putative 0.0156 0.0544 0.4931
Trichomonas vaginalis cyclins, putative 0.0075 0.0229 0.1877
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0099 0.0322 0.0324
Trichomonas vaginalis cyclin B, putative 0.0156 0.0544 0.4931
Trypanosoma brucei mitotic cyclin 0.0026 0.0035 0.0325
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0289 0.1068 1
Loa Loa (eye worm) cyclin C 0.0026 0.0035 0.0027
Loa Loa (eye worm) hypothetical protein 0.2489 0.9684 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0289 0.1068 1
Trypanosoma cruzi cyclin 9, putative 0.0026 0.0035 0.0325
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0322 0.0782
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0026 0.0035 0.0035
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0081 0.025 0.2341
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0008 0.002
Brugia malayi Cyclin, N-terminal domain containing protein 0.0156 0.0544 0.0536
Echinococcus granulosus cyclin dependent kinase 6 0.107 0.4124 0.4124
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0289 0.1068 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.025 0.025
Echinococcus multilocularis cyclin b3 0.0106 0.035 0.035
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0289 0.1068 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0081 0.025 0.2341
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0026 0.0035 0.0027
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0081 0.025 0.2341
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0099 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0049
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0026 0.0035 0.0462
Echinococcus granulosus cyclin G2 0.0026 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0049
Schistosoma mansoni cyclin l 0.0026 0.0035 0.0084
Toxoplasma gondii hypothetical protein 0.0081 0.025 0.3322
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0072 0.0357
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0209 0.0752 0.5
Loa Loa (eye worm) hypothetical protein 0.2281 0.8867 0.9155
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.257 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0081 0.025 0.3323
Echinococcus granulosus twitchin 0.0045 0.011 0.011
Echinococcus granulosus cGMP dependent protein kinase 1 0.0019 0.0008 0.0008
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0289 0.1068 1
Echinococcus multilocularis Immunoglobulin 0.0031 0.0055 0.0055
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0019 0.0008 0.0008
Echinococcus multilocularis cyclins 0.0106 0.035 0.035
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0081 0.025 0.0606
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0081 0.025 0.0242
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0081 0.025 0.2083
Schistosoma mansoni cyclin G2 0.0026 0.0035 0.0084
Schistosoma mansoni cyclins 0.0106 0.035 0.0849
Echinococcus granulosus Cyclin L1 0.0026 0.0035 0.0035
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0081 0.025 0.2341
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0081 0.025 0.0606
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0289 0.1068 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Plasmodium vivax protein kinase Crk2 0.0099 0.0322 0.4009
Echinococcus multilocularis cyclin k 0.0026 0.0035 0.0035
Trichomonas vaginalis cyclins, putative 0.0156 0.0544 0.4931
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0289 0.1068 1
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0752 0.6945
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0049
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0289 0.1068 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Echinococcus multilocularis cyclin dependent kinase 0.0099 0.0322 0.0322
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0081 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0062 0.0055
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Mycobacterium ulcerans putative regulatory protein 0.0209 0.0752 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0752 0.6945
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0752 0.6945
Plasmodium falciparum GAF domain-related protein, putative 0.0209 0.0752 1
Trichomonas vaginalis cyclin D, putative 0.0106 0.035 0.3054
Echinococcus granulosus cyclin dependent kinase 5 0.0099 0.0322 0.0322
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.025 0.2341
Schistosoma mansoni serine/threonine protein kinase 0.107 0.4124 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0081 0.025 0.2341
Echinococcus multilocularis neuroglian 0.0031 0.0055 0.0055
Echinococcus multilocularis cyclin y 0.0026 0.0035 0.0035
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0081 0.025 0.0242
Echinococcus granulosus cyclin G2 0.0026 0.0035 0.0035
Trypanosoma cruzi cyclin, putative 0.0156 0.0544 0.5096
Mycobacterium leprae conserved hypothetical protein 0.0209 0.0752 0.5
Echinococcus granulosus cyclins 0.0106 0.035 0.035
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0081 0.0081
Entamoeba histolytica cell division protein kinase 2, putative 0.0099 0.0322 0.5924
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0289 0.1068 0.2589
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0081 0.025 0.2341
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.025 0.2341
Toxoplasma gondii hypothetical protein 0.0209 0.0752 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0081 0.025 0.2083
Leishmania major hypothetical protein, conserved 0.0081 0.025 0.2341
Echinococcus multilocularis cyclin dependent kinase 6 0.107 0.4124 0.4124
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0026 0.0035 0.0462
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0099 0.0322 0.3019
Loa Loa (eye worm) CYL-1 protein 0.0026 0.0035 0.0027
Loa Loa (eye worm) hypothetical protein 0.0156 0.0544 0.0554
Trichomonas vaginalis cyclin B, putative 0.0106 0.035 0.3054
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0156 0.0544 0.5096
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0026 0.0035 0.0084
Echinococcus granulosus cyclins 0.0026 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0049
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0289 0.1068 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0035 0.0026
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0081 0.0075
Plasmodium falciparum cGMP-dependent protein kinase 0.0019 0.0008 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0322 0.0782
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0081 0.025 0.025
Brugia malayi hypothetical protein 0.0026 0.0035 0.0026
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0081 0.025 0.0606
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0027
Trypanosoma brucei cdc2-related kinase 3 0.0099 0.0322 0.3019
Onchocerca volvulus 0.0156 0.0544 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0289 0.1068 1
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0026 0.0035 0.0325
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0008 0.002
Trypanosoma cruzi CYC2-like cyclin, putative 0.0156 0.0544 0.5096
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0035 0.0026
Giardia lamblia hypothetical protein 0.0081 0.025 0.4225
Giardia lamblia Kinase, CMGC CDK 0.0099 0.0322 0.5647
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0026 0.0035 0.0027
Echinococcus granulosus roundabout 2 0.0031 0.0055 0.0055
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0026 0.0035 0.0462
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0017 0.0002 0.0023
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0099 0.0322 0.0324
Echinococcus granulosus cyclin k 0.0026 0.0035 0.0035
Schistosoma mansoni g1/s-specific cyclin C 0.0026 0.0035 0.0084
Echinococcus granulosus cyclin B3 1 0.0106 0.035 0.035
Echinococcus multilocularis expressed conserved protein 0.0019 0.0008 0.0008
Trypanosoma cruzi cyclin 6, putative 0.0156 0.0544 0.5096
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.025 0.2341
Echinococcus multilocularis Cyclin L1 0.0026 0.0035 0.0035
Trichomonas vaginalis cyclins, putative 0.0156 0.0544 0.4931
Entamoeba histolytica cyclin family protein 0.0106 0.035 0.6436
Echinococcus granulosus cyclin t1 0.0026 0.0035 0.0035
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Loa Loa (eye worm) cyclin domain-containing protein 0.0026 0.0035 0.0027
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0099 0.0322 0.0324
Echinococcus multilocularis cyclin 0.0026 0.0035 0.0035
Entamoeba histolytica cyclin, putative 0.0156 0.0544 1
Echinococcus granulosus cyclin y 0.0026 0.0035 0.0035
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0081 0.025 0.2083
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0095 0.023
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0081 0.025 0.0242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Brugia malayi Protein kinase domain containing protein 0.0099 0.0322 0.0314
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0289 0.1068 1
Schistosoma mansoni cyclin B 0.0156 0.0544 0.1319
Trichomonas vaginalis cyclin B, putative 0.0156 0.0544 0.4931
Toxoplasma gondii hypothetical protein 0.0209 0.0752 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0081 0.025 0.0606
Brugia malayi cyclin fold protein 1 variant b 0.0026 0.0035 0.0026
Echinococcus multilocularis cyclin dependent kinase 5 0.0099 0.0322 0.0322
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0099 0.0322 0.3019
Echinococcus granulosus cyclins 0.0106 0.035 0.035
Brugia malayi Cyclin C 0.0026 0.0035 0.0026
Trichomonas vaginalis cyclins, putative 0.0106 0.035 0.3054
Entamoeba histolytica cyclin C, putative 0.0026 0.0035 0.0638
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0019 0.0008 0.0008
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0026 0.0035 0.0035
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0081 0.025 0.3323
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0035 0.0026
Loa Loa (eye worm) cyclin domain-containing protein 0.0106 0.035 0.0353
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0035 0.0026
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0081 0.025 0.2341
Trypanosoma cruzi mitotic cyclin, putative 0.0026 0.0035 0.0325
Giardia lamblia G2/mitotic-specific cyclin B 0.0156 0.0544 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0081 0.025 0.025
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0081 0.025 0.0606
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0081 0.025 0.0606
Echinococcus multilocularis cyclin G2 0.0026 0.0035 0.0035
Echinococcus multilocularis cyclins 0.0106 0.035 0.035
Brugia malayi hypothetical protein 0.0031 0.0055 0.0047
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0081 0.025 0.2083
Schistosoma mansoni cyclin d 0.0026 0.0035 0.0084
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0083 0.026 0.3452
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0083 0.026 0.3452
Plasmodium vivax hypothetical protein, conserved 0.0209 0.0752 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0081 0.025 0.3
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0289 0.1068 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0081 0.025 0.2341
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Echinococcus granulosus cyclin dependent kinase 0.0099 0.0322 0.0322
Giardia lamblia Kinase, CMGC CDK 0.0099 0.0322 0.5647
Trypanosoma brucei cyclin 3 0.0026 0.0035 0.0325
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Echinococcus granulosus cyclin y 0.0026 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0289 0.1068 0.1095
Schistosoma mansoni vesicular amine transporter 0.0033 0.0065 0.0158
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0081 0.025 0.025
Loa Loa (eye worm) cyclin domain-containing protein 0.0026 0.0035 0.0027
Echinococcus granulosus cyclin B 0.0156 0.0544 0.0544
Schistosoma mansoni cyclin k 0.0026 0.0035 0.0084
Trypanosoma cruzi cyclin, putative 0.0156 0.0544 0.5096
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0081 0.025 0.2083
Toxoplasma gondii GAF domain-containing protein 0.0209 0.0752 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0209 0.0752 0.5
Entamoeba histolytica cyclin, domain containing protein 0.0026 0.0035 0.0638
Echinococcus multilocularis cyclins 0.0106 0.035 0.035
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0081 0.025 0.3323
Brugia malayi hypothetical protein 0.0026 0.0035 0.0026
Loa Loa (eye worm) cyclin domain-containing protein 0.0026 0.0035 0.0027
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0049
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0055 0.0047
Toxoplasma gondii hypothetical protein 0.0026 0.0035 0.0462
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0049
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Giardia lamblia Hypothetical protein 0.0106 0.035 0.6193
Echinococcus granulosus cyclins 0.0106 0.035 0.035
Trypanosoma brucei cdc2-related kinase 1 0.0099 0.0322 0.3019
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0081 0.025 0.025
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0026 0.0035 0.0035
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Echinococcus granulosus neuroglian 0.0031 0.0055 0.0055
Brugia malayi Cyclin, N-terminal domain containing protein 0.0026 0.0035 0.0026
Echinococcus multilocularis cyclins 0.0106 0.035 0.035
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0031 0.0055 0.0055
Plasmodium falciparum protein kinase 5 0.0099 0.0322 0.4285
Echinococcus granulosus cGMP dependent protein kinase 1 0.0019 0.0008 0.0008
Loa Loa (eye worm) cyclin domain-containing protein 0.0026 0.0035 0.0027
Leishmania major hypothetical protein, conserved 0.0081 0.025 0.2341
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Trypanosoma cruzi cdc2-related kinase 3 0.0099 0.0322 0.3019
Schistosoma mansoni cyclin B3 0.0106 0.035 0.0849
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.025 0.2341
Plasmodium falciparum phosphodiesterase delta, putative 0.0081 0.025 0.3323
Trypanosoma brucei mitotic cyclin 6 0.0156 0.0544 0.5096
Leishmania major cyclin 0.0156 0.0544 0.5096
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0081 0.025 0.2083
Trichomonas vaginalis cyclin A, putative 0.0156 0.0544 0.4931
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0031 0.0055 0.0135
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0289 0.1068 0.2589
Brugia malayi Fibronectin type III domain containing protein 0.0031 0.0055 0.0047
Trypanosoma brucei cyclin 9 0.0026 0.0035 0.0325
Loa Loa (eye worm) hypothetical protein 0.0156 0.0544 0.0554
Giardia lamblia Cyclin A 0.0106 0.035 0.6193
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0008 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.025 0.2341
Echinococcus granulosus cyclins 0.0106 0.035 0.035
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0026 0.0035 0.0035
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0289 0.1068 0.106
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0066 0.0058
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0081 0.025 0.0242
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.257 1 1
Trypanosoma cruzi cdc2-related kinase 3 0.0099 0.0322 0.3019
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0081 0.025 0.0606
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Trichomonas vaginalis cyclins, putative 0.0156 0.0544 0.4931
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0289 0.1068 1
Echinococcus granulosus Immunoglobulin 0.0031 0.0055 0.0055
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0081 0.025 0.2341
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Leishmania major mitotic cyclin, putative 0.0026 0.0035 0.0325
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0209 0.0752 0.5
Schistosoma mansoni nephrin 0.0031 0.0055 0.0135
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0081 0.025 0.2083
Echinococcus multilocularis Immunoglobulin 0.0031 0.0055 0.0055
Trypanosoma cruzi cdc2-related kinase 1 0.0099 0.0322 0.3019
Echinococcus granulosus cGMP dependent protein kinase 0.0019 0.0008 0.0008
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0019 0.0008 0.0112
Entamoeba histolytica cell division protein kinase 2, putative 0.0099 0.0322 0.5924
Echinococcus granulosus cyclin dependent kinase 1 0.0099 0.0322 0.0322
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0081 0.025 0.2083
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0081 0.025 0.3
Brugia malayi Cyclin, N-terminal domain containing protein 0.0156 0.0544 0.0536
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0322 0.2784
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0099 0.0322 0.4285
Echinococcus granulosus cyclin 0.0026 0.0035 0.0035
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0034 0.0066 0.006
Echinococcus multilocularis cyclins 0.0106 0.035 0.035
Schistosoma mansoni hypothetical protein 0.0026 0.0035 0.0084
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0081 0.025 0.2341
Echinococcus multilocularis cyclins 0.0106 0.035 0.035
Entamoeba histolytica cyclin, domain containing protein 0.0026 0.0035 0.0638
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0081 0.025 0.2083
Echinococcus multilocularis cyclin dependent kinase 1 0.0099 0.0322 0.0322
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0081 0.025 0.025
Toxoplasma gondii cyclin 4, putative 0.0026 0.0035 0.0462
Trichomonas vaginalis cyclin B, putative 0.0156 0.0544 0.4931
Trichomonas vaginalis cyclin B3, putative 0.0106 0.035 0.3054
Leishmania major protein kinase, putative 0.0019 0.0008 0.0079
Trichomonas vaginalis cyclins, putative 0.0156 0.0544 0.4931
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0081 0.025 0.0606
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0081 0.025 0.3
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0322 0.2784
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0026 0.0035 0.0462
Schistosoma mansoni Cyclin fold protein 0.0026 0.0035 0.0084
Loa Loa (eye worm) hypothetical protein 0.0085 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0081 0.025 0.025
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0072 0.0357
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Leishmania major cyclin 9, putative 0.0026 0.0035 0.0325
Loa Loa (eye worm) hypothetical protein 0.0081 0.025 0.025
Echinococcus multilocularis cyclin B3 1 0.0106 0.035 0.035
Brugia malayi Cyclin, N-terminal domain containing protein 0.0106 0.035 0.0342
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Echinococcus multilocularis cyclin B 0.0156 0.0544 0.0544
Echinococcus multilocularis G1:S specific cyclin D1 0.0026 0.0035 0.0035
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0081 0.025 0.2083
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0081 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.0752 0.6945
Loa Loa (eye worm) hypothetical protein 0.005 0.0128 0.0124
Plasmodium falciparum cyclin 1 0.0026 0.0035 0.0462
Schistosoma mansoni hypothetical protein 0.0026 0.0035 0.0084
Mycobacterium ulcerans putative regulatory protein 0.0209 0.0752 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0289 0.1068 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0081 0.025 0.4225
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0081 0.025 0.025
Toxoplasma gondii cyclin dependent kinase binding protein 0.0026 0.0035 0.0462
Echinococcus granulosus cyclins 0.0106 0.035 0.035
Leishmania major protein kinase, putative 0.0019 0.0008 0.0079
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0289 0.1068 1
Schistosoma mansoni cell adhesion molecule 0.0031 0.0055 0.0135
Trichomonas vaginalis cyclin D, putative 0.0106 0.035 0.3054
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0289 0.1068 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0289 0.1068 1
Echinococcus granulosus cyclin b3 0.0106 0.035 0.035
Toxoplasma gondii hypothetical protein 0.0209 0.0752 1
Echinococcus multilocularis cyclin t1 0.0026 0.0035 0.0035
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0031 0.0055 0.0055
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0081 0.025 0.025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0081 0.025 0.3323
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.025 0.2083
Plasmodium falciparum phosphodiesterase gamma, putative 0.0081 0.025 0.3323
Echinococcus granulosus G1:S specific cyclin D1 0.0026 0.0035 0.0035
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0031 0.0055 0.0135
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0081 0.025 0.2083
Loa Loa (eye worm) cyclin domain-containing protein 0.0026 0.0035 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.035 0.3054
Brugia malayi cell division control protein 2 homolog 0.0099 0.0322 0.0314
Loa Loa (eye worm) PDE1B protein 0.0081 0.025 0.025
Echinococcus multilocularis roundabout 2 0.0031 0.0055 0.0055
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0106 0.035 0.035
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Plasmodium falciparum cyclin 0.0106 0.035 0.4656
Trypanosoma cruzi cdc2-related kinase 1 0.0099 0.0322 0.3019
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0081 0.025 0.2341
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0081 0.0081
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0289 0.1068 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0099 0.0322 0.0322
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0081 0.025 0.025
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0106 0.035 0.035
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0289 0.1068 0.1068
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0081 0.025 0.025
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0081 0.025 0.025
Echinococcus multilocularis cyclin A3 4 0.0026 0.0035 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.0099 0.0322 0.2784
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0289 0.1068 0.1068
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.025 0.2083
Trypanosoma cruzi mitotic cyclin, putative 0.0026 0.0035 0.0325
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0049
Schistosoma mansoni cyclin G 0.0026 0.0035 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0035 0.0325
Entamoeba histolytica cyclin family protein 0.0106 0.035 0.6436

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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