Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ketohexokinase (fructokinase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Onchocerca volvulus | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | ribokinase, putative | ketohexokinase (fructokinase) | 298 aa | 307 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0577 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0092 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0312 | 0.4545 | 0.4545 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.4545 | 0.4545 |
Toxoplasma gondii | hypothetical protein | 0.0092 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0092 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0092 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0577 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0 | 0.5 |
Onchocerca volvulus | 0.0312 | 0.4545 | 0.4545 | |
Leishmania major | glutaminyl cyclase, putative | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0092 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0092 | 0 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0092 | 0 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0577 | 1 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0577 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0092 | 0 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0092 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7 nM | Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluorescence polarization assay | ChEMBL. | 24900346 |
IC50 (binding) | = 140 nM | Inhibition of ketokinase isoform C in human HepG2 cells assessed as levels of fructose-1-phosphate preincubated for 30 mins followed by substrate addition measured after 3 hrs by LC-MS analysis | ChEMBL. | 24900346 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.