Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 7 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | cholinergic receptor, nicotinic, alpha 7 (neuronal) | 502 aa | 513 aa | 33.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.021 | 1 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.021 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.021 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0101 | 0.3612 | 0.3217 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3612 | 0.3612 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.021 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.021 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.021 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.021 | 1 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.021 | 1 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.021 | 1 | 0.5 |
Brugia malayi | Cation transporter family protein | 0.0101 | 0.3612 | 0.3385 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.021 | 1 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.021 | 1 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.021 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3612 | 0.3612 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.021 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.021 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.021 | 1 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.021 | 1 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.021 | 1 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0343 | 0.0343 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.021 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.021 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0101 | 0.3612 | 0.3217 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.021 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.021 | 1 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.021 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3207 | 0.3207 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 6.4 | Agonist activity at human alpha7 nAChR expressed in GH4C1 cells by FLIPR assay | ChEMBL. | 22503248 |
IC50 (binding) | = 5.4 | Displacement of [3H]Dofetilide from human ERG expressed in CHO-K1 cells by scintillation proximity assay | ChEMBL. | 22503248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.