Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyl diphosphate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.0327 | 0.2574 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0914 | 1 | 1 |
Onchocerca volvulus | 0.0202 | 0.0986 | 0.2464 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0327 | 0.2574 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0327 | 0.2574 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0327 | 0.2574 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0327 | 0.2574 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0327 | 0.2574 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0327 | 0.2574 | 1 |
Mycobacterium ulcerans | phosphoribosylaminoimidazole synthetase | 0.0202 | 0.0986 | 0.0986 |
Onchocerca volvulus | 0.0327 | 0.2574 | 1 | |
Brugia malayi | thymidylate synthase | 0.0327 | 0.2574 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0327 | 0.2574 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt | 0.0133 | 0.0122 | 0.0472 |
Mycobacterium ulcerans | thymidylate synthase | 0.0327 | 0.2574 | 0.2574 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0156 | 0.0403 | 0.1566 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0327 | 0.2574 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0327 | 0.2574 | 1 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.0124 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0202 | 0.0986 | 0.3832 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0327 | 0.2574 | 0.1761 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0914 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0327 | 0.2574 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0156 | 0.0403 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0156 | 0.0403 | 0.1566 |
Brugia malayi | hypothetical protein | 0.0156 | 0.0403 | 0.1566 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 200 ug kg-1 | Effective dose in inhibiting osteoclastic bone resorption | ChEMBL. | 12825934 |
ED50 (functional) | = 200 ug kg-1 | Effective dose after subcutaneous administration to TPTX rats for 50% reduction of hypercalcemia | ChEMBL. | 12166945 |
ED50 (functional) | = 200 ug kg-1 | Effective dose in inhibiting osteoclastic bone resorption | ChEMBL. | 12825934 |
IC50 (functional) | = -6.222 | Negative logarithm of inhibitory concentration against bone resorption | ChEMBL. | 12825934 |
Log IC50 (functional) | = 6.222 | Negative logarithm of inhibitory concentration against bone resorption | ChEMBL. | 12825934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.