Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.1111 | 0.4591 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.0304 | 0.8342 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0524 | 0.2091 | 0.455 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.1111 | 0.4591 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0524 | 0.2091 | 0.455 |
Schistosoma mansoni | coup transcription factor | 0.1111 | 0.4591 | 0.4591 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.1111 | 0.4591 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1111 | 0.4591 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0524 | 0.2091 | 0.4556 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0054 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1111 | 0.4591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0587 | 0.2359 | 0.5139 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0524 | 0.2091 | 0.4556 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0524 | 0.2091 | 0.455 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0524 | 0.2091 | 0.455 |
Brugia malayi | nuclear receptor NHR-88 | 0.0524 | 0.2091 | 0.4556 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0524 | 0.2091 | 0.4556 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1111 | 0.4591 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.1111 | 0.4591 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0524 | 0.2091 | 0.4556 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.0027 | 0.0047 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.1111 | 0.4591 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.0304 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0524 | 0.2091 | 0.4556 |
Schistosoma mansoni | nuclear hormone receptor | 0.1111 | 0.4591 | 0.4591 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0054 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0008 | 0.0006 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1111 | 0.4591 | 1 |
Onchocerca volvulus | 0.1111 | 0.4591 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.1111 | 0.4591 | 0.4591 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0008 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0587 | 0.2359 | 0.5139 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.0304 | 0.8342 |
Schistosoma mansoni | thyroid hormone receptor | 0.1111 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0524 | 0.2091 | 0.4556 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.1111 | 0.4591 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0092 | 0.0253 | 0.0541 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0005 | 0.0011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.1111 | 0.4591 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.1111 | 0.4591 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0054 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1111 | 0.4591 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0092 | 0.0253 | 0.0551 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.1111 | 0.4591 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1111 | 0.4591 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.1111 | 0.4591 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1111 | 0.4591 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0524 | 0.2091 | 0.455 |
Schistosoma mansoni | nuclear hormone receptor | 0.0524 | 0.2091 | 0.2091 |
Brugia malayi | steroid hormone receptor | 0.1111 | 0.4591 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1111 | 0.4591 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.1111 | 0.4591 | 1 |
Brugia malayi | ecdysone receptor | 0.0524 | 0.2091 | 0.4556 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0054 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0587 | 0.2359 | 0.5139 |
Brugia malayi | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Loa Loa (eye worm) | hypothetical protein | 0.0587 | 0.2359 | 0.5139 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0524 | 0.2091 | 0.4556 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0587 | 0.2359 | 0.5139 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1111 | 0.4591 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0008 | 0.0006 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0054 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.1111 | 0.4591 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0073 | 0.0172 | 0.0172 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0524 | 0.2091 | 0.455 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0065 | 0.0142 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.1111 | 0.4591 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0008 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0065 | 0.0142 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.1111 | 0.4591 | 1 |
Brugia malayi | ecdysteroid receptor | 0.1111 | 0.4591 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0524 | 0.2091 | 0.4556 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0054 | 0.5 |
Brugia malayi | hypothetical protein | 0.0587 | 0.2359 | 0.5139 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.1111 | 0.4591 | 0.4591 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0587 | 0.2359 | 0.2359 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1111 | 0.4591 | 1 |
Brugia malayi | tailless protein | 0.0524 | 0.2091 | 0.4556 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.1111 | 0.4591 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0524 | 0.2091 | 0.4556 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1111 | 0.4591 | 0.4591 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0008 | 0.0017 |
Brugia malayi | nuclear receptor RXR | 0.0524 | 0.2091 | 0.4556 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0054 | 0.0119 |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.0005 | 0.0011 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0054 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1111 | 0.4591 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0524 | 0.2091 | 0.2091 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1111 | 0.4591 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0524 | 0.2091 | 0.4556 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.0354 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0524 | 0.2091 | 0.4556 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1111 | 0.4591 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0524 | 0.2091 | 0.455 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0524 | 0.2091 | 0.2091 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0066 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.1111 | 0.4591 | 0.4591 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.0354 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1111 | 0.4591 | 1 |
Brugia malayi | nuclear hormone receptor | 0.1111 | 0.4591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.1111 | 0.4591 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0524 | 0.2091 | 0.2091 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0054 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.1111 | 0.4591 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.1111 | 0.4591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1111 | 0.4591 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.1111 | 0.4591 | 0.4591 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0524 | 0.2091 | 0.455 |
Loa Loa (eye worm) | hypothetical protein | 0.1111 | 0.4591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Schistosoma mansoni | nuclear receptor | 0.0524 | 0.2091 | 0.2091 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.1111 | 0.4591 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.1111 | 0.4591 | 1 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0054 | 0.0119 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.0304 | 0.8342 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.1111 | 0.4591 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0524 | 0.2091 | 0.4556 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0054 | 0.0108 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.0354 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0587 | 0.2359 | 0.5139 |
Brugia malayi | nuclear receptor NHR-88 | 0.1111 | 0.4591 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0008 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0587 | 0.2359 | 0.5133 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.1111 | 0.4591 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0054 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1111 | 0.4591 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1111 | 0.4591 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0524 | 0.2091 | 0.455 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0054 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.1111 | 0.4591 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0092 | 0.0253 | 0.0541 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.1111 | 0.4591 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.0304 | 0.8342 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.1111 | 0.4591 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1111 | 0.4591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1111 | 0.4591 | 1 |
Brugia malayi | hypothetical protein | 0.0587 | 0.2359 | 0.5139 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0005 | 0.0005 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0587 | 0.2359 | 0.5133 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.0027 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.1111 | 0.4591 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.1111 | 0.4591 | 0.4591 |
Schistosoma mansoni | zinc finger protein | 0.0524 | 0.2091 | 0.2091 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.1111 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | hypothetical protein | 0.0587 | 0.2359 | 0.5139 |
Brugia malayi | nuclear receptor RXR | 0.0587 | 0.2359 | 0.5139 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0054 | 0.0108 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0008 | 0.0008 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.1111 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.0108 | 0.0235 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0065 | 0.0142 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.1111 | 0.4591 | 0.4591 |
Schistosoma mansoni | nuclear receptor | 0.0524 | 0.2091 | 0.2091 |
Loa Loa (eye worm) | hypothetical protein | 0.1111 | 0.4591 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.0304 | 0.8342 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.0354 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0005 | 0.0005 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.1111 | 0.4591 | 0.4591 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0008 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.1111 | 0.4591 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0524 | 0.2091 | 0.455 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.1111 | 0.4591 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0524 | 0.2091 | 0.455 |
Loa Loa (eye worm) | hypothetical protein | 0.1111 | 0.4591 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0587 | 0.2359 | 0.2359 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.1111 | 0.4591 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0524 | 0.2091 | 0.455 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0524 | 0.2091 | 0.4556 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Brugia malayi | hypothetical protein | 0.0524 | 0.2091 | 0.4556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.1111 | 0.4591 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0065 | 0.0142 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0587 | 0.2359 | 0.5139 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.1111 | 0.4591 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.287 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.