TDR Targets

Basic information

Technical information

TDR Targets ID: 1648827
Name: 1-tert-butyl-3-(pyridin-2-ylmethylideneamino) thiourea
MW: 236.337 | Formula: C11H16N4S
H donors: 2 H acceptors: 1 LogP: 1.85 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: S=C(NC(C)(C)C)N/N=C/c1ccccn1
InChi: 1S/C11H16N4S/c1-11(2,3)14-10(16)15-13-8-9-6-4-5-7-12-9/h4-8H,1-3H3,(H2,14,15,16)/b13-8+
InChiKey: ULLQNBIDEXPKQN-MDWZMJQESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-tert-butyl-3-(2-pyridylmethyleneamino)thiourea
2-Pyridinecarbaldehyde N-(tert-butyl)thiosemicarbazone
NCI60_024936
NSC670786
AIDS-161098
AIDS161098

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0429	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Echinococcus granulosus	nAChR subunit	0.0087	0.1739	0.8137
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0166	0.3622	0.5495
Schistosoma mansoni	glucose transport protein	0.0103	0.2128	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.055	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0429	0.1855
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0445	0.0404
Brugia malayi	Cam kinase protein 1	0.0032	0.0444	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0433	0.9906	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0166	0.3622	0.3595
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0087	0.1739	0.8137
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0087	0.1739	0.1756
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0087	0.1739	0.1756
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1927
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0087	0.1739	0.1756
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2128	1
Onchocerca volvulus		0.0087	0.1739	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0429	0.0433
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.004	0.0641	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0799	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1927
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.395
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2128	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0047	0.0799	0.0767
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0047	0.0799	0.0767
Leishmania major	glucose transporter, lmgt3	0.0032	0.0454	0.8107
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0087	0.1739	0.8137
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.055	0.0779
Echinococcus granulosus	glycine receptor subunit beta	0.0087	0.1739	0.8137
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0087	0.1739	0.8137
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Schistosoma mansoni	nAChR subunit	0.0087	0.1739	0.8137
Loa Loa (eye worm)	ACC-1 protein	0.0087	0.1739	0.1756
Loa Loa (eye worm)	sugar transporter	0.0103	0.2128	0.2148
Schistosoma mansoni	nAChR subunit	0.0087	0.1739	0.8137
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0176	0.0641
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0454	0.8107
Loa Loa (eye worm)	acetylcholine receptor protein	0.004	0.0641	0.0647
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1927
Schistosoma mansoni	protein kinase	0.0032	0.0444	0.1927
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0087	0.1739	0.172
Schistosoma mansoni	nAChR subunit	0.004	0.0641	0.2872
Schistosoma mansoni	protein kinase	0.0032	0.0444	0.1927
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0243	0.0961
Plasmodium falciparum	protein kinase 7	0.0291	0.6557	0.6542
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0087	0.1739	0.8137
Echinococcus multilocularis	glycine receptor subunit beta	0.0087	0.1739	0.8137
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0429	0.1855
Schistosoma mansoni	glucose transport protein	0.0103	0.2128	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0243	0.0203
Plasmodium vivax	hexose transporter	0.0103	0.2128	0.2094
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0087	0.1739	0.8137
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Echinococcus multilocularis	glycine receptor subunit beta	0.0087	0.1739	0.8137
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0398	0.1707
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.004	0.0641	0.0607
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0243	1
Trypanosoma cruzi	hexose transporter	0.0032	0.0454	0.8107
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0087	0.1739	0.8137
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0799	0.0807
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Brugia malayi	hypothetical protein	0.004	0.0641	0.0607
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0087	0.1739	0.8137
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0103	0.2128	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0087	0.1739	0.172
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0087	0.1739	0.8137
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0087	0.1739	0.8137
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0087	0.1739	0.172
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0087	0.1739	0.172
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0087	0.1739	0.8137
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0087	0.1739	0.8137
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0087	0.1739	0.8137
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0042	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0799	0.0807
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0398	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0799	0.0807
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0113	0.1383
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0429	0.1855
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0445	0.0404
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0087	0.1739	0.8137
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0445	0.0404
Onchocerca volvulus		0.0087	0.1739	1
Schistosoma mansoni	nAChR subunit	0.0087	0.1739	0.8137
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0444	0.1927
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.055	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0243	0.0201
Schistosoma mansoni	protein kinase	0.0032	0.0444	0.1927
Schistosoma mansoni	nAChR subunit	0.0087	0.1739	0.8137
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0087	0.1739	0.8137
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0087	0.1739	0.8137
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0454	0.1973
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0445	0.0617
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.004	0.0641	0.2872
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.004	0.0641	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0429	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0799	0.0807
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0454	0.8107
Brugia malayi	Cation transporter family protein	0.0087	0.1739	0.172
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2128	1
Brugia malayi	hypothetical protein	0.004	0.0641	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0087	0.1739	0.1756
Loa Loa (eye worm)	sugar transporter	0.0014	0.0042	0.0043
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0087	0.1739	0.8137
Schistosoma mansoni	neurotransmitter gated ion channel	0.004	0.0641	0.2872
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0445	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.395
Leishmania major	protein kinase, putative	0.0032	0.0444	0.7919
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0243	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0444	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0799	0.0807
Schistosoma mansoni	acetylcholine receptor-related	0.004	0.0641	0.2872
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.0245
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0429	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0047	0.0799	0.0767
Loa Loa (eye worm)	GABA receptor subunit	0.0047	0.0799	0.0807
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0047	0.0799	0.3629
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0042	0.0043
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0454	0.8107
Onchocerca volvulus		0.0087	0.1739	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0445	0.0404
Onchocerca volvulus		0.0087	0.1739	1
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0047	0.0799	0.0767
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.004	0.0641	0.0607
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0087	0.1739	0.8137
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0161	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0087	0.1739	0.172
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Onchocerca volvulus		0.0087	0.1739	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.055	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1927
Onchocerca volvulus		0.004	0.0641	0.353
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0454	0.1973
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0445	0.0404
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Schistosoma mansoni	hypothetical protein	0.0103	0.2128	1
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0087	0.1739	0.172
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0087	0.1739	0.172
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0429	0.0392
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0087	0.1739	0.1756
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.004	0.0641	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0444	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Brugia malayi	hypothetical protein	0.004	0.0641	0.0607
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0454	0.1973
Echinococcus multilocularis	nAChR subunit	0.0087	0.1739	0.8137
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0429	0.335
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Plasmodium falciparum	hexose transporter	0.0103	0.2128	0.2094
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.004	0.0641	0.0607
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0166	0.3622	0.3595
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0087	0.1739	0.8137
Loa Loa (eye worm)	hypothetical protein	0.0393	0.8966	0.9051
Echinococcus granulosus	General substrate transporter	0.0089	0.1787	0.8364
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0087	0.1739	0.172
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.055	0.051
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0293	0.0295
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0454	0.1973
Schistosoma mansoni	glucose transport protein	0.0103	0.2128	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0444	0.7919
Onchocerca volvulus		0.0047	0.0799	0.446
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0445	0.0617
Echinococcus multilocularis	nAChR subunit	0.0047	0.0799	0.3629
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.004	0.0641	0.2872
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0243	0.3046
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0087	0.1739	0.8137
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0433	0.9906	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0087	0.1739	0.8137
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Onchocerca volvulus		0.004	0.0641	0.353
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0444	0.0448
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.055	1
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0243	0.0201
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0243	0.0308
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1927
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0087	0.1739	0.8137
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0243	0.0961
Brugia malayi	Sugar transporter family protein	0.0103	0.2128	0.2114
Onchocerca volvulus		0.004	0.0641	0.353
Loa Loa (eye worm)	hypothetical protein	0.0414	0.9452	0.9542
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Schistosoma mansoni	nAChR subunit	0.0087	0.1739	0.8137
Brugia malayi	Cation transporter family protein	0.0087	0.1739	0.172
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0444	0.0407
Schistosoma mansoni	neurotransmitter gated ion channel	0.0047	0.0799	0.3629
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1927
Loa Loa (eye worm)	ACC-1 protein	0.0087	0.1739	0.1756
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.004	0.0641	0.0607
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0087	0.1739	0.172
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0429	0.0392
Schistosoma mansoni	nAChR subunit	0.0087	0.1739	0.8137
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.0961
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.004	0.0641	0.2872
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0445	0.0404
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Echinococcus granulosus	glycine receptor subunit beta	0.0087	0.1739	0.8137
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0087	0.1739	0.8137
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0161	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0799	0.0807
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0087	0.1739	0.8137
Entamoeba histolytica	hypothetical protein	0.0047	0.0799	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0087	0.1739	0.8137
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0087	0.1739	0.172
Onchocerca volvulus		0.0047	0.0799	0.446
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0444	0.0448
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0429	0.1855
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0429	0.1855
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0445	0.0404
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2128	1
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0454	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2128	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0445	0.0617
Echinococcus multilocularis	General substrate transporter	0.0089	0.1787	0.8364
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0454	0.8107
Schistosoma mansoni	acetylcholine receptor subunit beta	0.004	0.0641	0.2872
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0437	1	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.395
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0444	0.1927
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2128	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0444	0.1927
Brugia malayi	hypothetical protein	0.004	0.0641	0.0607
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2128	1
Brugia malayi	Cation transporter family protein	0.0087	0.1739	0.172
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0243	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0087	0.1739	0.172
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0087	0.1739	0.8137
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0042	0.5
Brugia malayi	excitatory GABA receptor EXP-1A	0.0087	0.1739	0.172
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Toxoplasma gondii	protein kinase, putative	0.0291	0.6557	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0454	0.8107
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.004	0.0641	0.2872
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0454	0.1973
Leishmania major	glucose transporter, lmgt1	0.0032	0.0454	0.8107
Entamoeba histolytica	protein kinase, putative	0.0032	0.0444	0.3621
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.2128	1
Echinococcus granulosus	nAChR subunit	0.0047	0.0799	0.3629
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Toxoplasma gondii	facilitative glucose transporter GT1	0.0103	0.2128	0.3201
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0243	0.0961
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.055	0.051
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0087	0.1739	0.8137
Schistosoma mansoni	nAChR subunit	0.004	0.0641	0.2872
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.004	0.0641	0.0607
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0087	0.1739	0.172
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0243	0.5182
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.8107
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.004	0.0641	0.2872
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Onchocerca volvulus		0.0087	0.1739	1
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0087	0.1739	0.172
Onchocerca volvulus	Putative nachr subunit	0.0087	0.1739	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0087	0.1739	0.8137
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0454	0.8107
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0454	0.8107
Entamoeba histolytica	protein kinase, putative	0.0032	0.0444	0.3621
Schistosoma mansoni	neurotransmitter gated ion channel	0.004	0.0641	0.2872
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0799	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0087	0.1739	0.172
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0087	0.1739	0.172
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0047	0.0799	0.3629
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1739	0.1756
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0454	0.1973
Leishmania major	glucose transporter, lmgt2	0.0032	0.0454	0.8107
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0087	0.1739	0.1756
Loa Loa (eye worm)	hypothetical protein	0.004	0.0641	0.0647
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.055	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0445	0.0404
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0243	0.0961
Schistosoma mansoni	nAChR subunit	0.0087	0.1739	0.8137
Brugia malayi	hypothetical protein	0.004	0.0641	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0043
Loa Loa (eye worm)	LGC-31 protein	0.0087	0.1739	0.1756

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-8	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-7.625	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-7.107	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.586	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.388	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.8	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.691	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.576	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.5	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.484	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.429	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2006241

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1648827