Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0374 | 0.4464 | 0.4464 |
Loa Loa (eye worm) | raf kinase | 0.0421 | 0.5126 | 0.5801 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0152 | 0.1323 | 0.1323 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 0.298 | 0.3372 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0096 | 0.0522 | 0.1047 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0765 | 1 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0143 | 0.1197 | 0.2401 |
Loa Loa (eye worm) | phosphatidylinositol 4-kinase type 3 alpha isoform 1 | 0.0061 | 0.0034 | 0.0039 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0406 | 0.0814 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0122 | 0.09 | 0.1018 |
Echinococcus granulosus | phosphatidylinositol 4 kinase alpha | 0.0061 | 0.0034 | 0.0034 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0407 | 0.0817 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0423 | 0.5155 | 0.5155 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0152 | 0.1323 | 0.1323 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.0061 | 0.0034 | 0.0257 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0124 | 0.0916 | 0.1837 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0423 | 0.5155 | 0.5155 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0152 | 0.1323 | 0.2653 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0061 | 0.0034 | 0.0068 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0285 | 0.3203 | 0.6424 |
Trypanosoma brucei | phosphatidylinositol 4-kinase alpha, putative | 0.0061 | 0.0034 | 0.0257 |
Loa Loa (eye worm) | TTK protein kinase | 0.0374 | 0.4464 | 0.5052 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0103 | 0.0625 | 0.1253 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0116 | 0.0813 | 0.163 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0061 | 0.0034 | 0.0068 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0143 | 0.1197 | 0.2348 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0124 | 0.0916 | 0.1837 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0095 | 0.051 | 0.1023 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0411 | 0.4986 | 1 |
Giardia lamblia | GTOR | 0.0152 | 0.1323 | 0.182 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0152 | 0.1323 | 0.1497 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0143 | 0.1197 | 0.2401 |
Plasmodium falciparum | phosphatidylinositol 3-kinase | 0.0061 | 0.0034 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0116 | 0.0813 | 0.163 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.117 | 0.1324 |
Schistosoma mansoni | phosphatidylinositol 4-kinase | 0.0061 | 0.0034 | 0.0034 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0152 | 0.1323 | 0.2653 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0143 | 0.1197 | 0.2401 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0143 | 0.1197 | 0.9047 |
Brugia malayi | Raf kinase | 0.0408 | 0.4946 | 0.9921 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0124 | 0.0916 | 0.1837 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0078 | 0.0274 | 0.207 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0285 | 0.3203 | 0.6424 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase, putative | 0.0122 | 0.09 | 0.1805 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0095 | 0.051 | 0.1023 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0152 | 0.1323 | 0.2603 |
Brugia malayi | phosphatidylinositol 4-kinase, catalytic, alpha polypeptide | 0.0061 | 0.0034 | 0.0068 |
Echinococcus granulosus | phosphatidylinositol 3 kinase catalytic subunit | 0.0061 | 0.0034 | 0.0034 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0116 | 0.0813 | 0.163 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0187 | 0.1817 | 0.3601 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.024 | 0.2561 | 0.2898 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0143 | 0.1197 | 0.2348 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0407 | 0.0817 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0152 | 0.1323 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0152 | 0.1323 | 0.2653 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0374 | 0.4464 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0116 | 0.0813 | 0.163 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0411 | 0.4986 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0124 | 0.0917 | 0.6934 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.039 | 0.4689 | 0.94 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0423 | 0.5155 | 0.5155 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0116 | 0.0813 | 0.163 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0116 | 0.0813 | 0.163 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0152 | 0.1323 | 1 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0061 | 0.0034 | 0.0068 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0152 | 0.1323 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0124 | 0.0916 | 0.1837 |
Trichomonas vaginalis | phosphatidylinositol 4-kinase, putative | 0.0061 | 0.0034 | 0.0068 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0354 | 0.4178 | 0.8381 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0374 | 0.4464 | 0.4464 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0124 | 0.0917 | 0.6934 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0143 | 0.1197 | 0.2401 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0203 | 0.204 | 0.3687 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0152 | 0.1323 | 1 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0765 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0329 | 0.3823 | 0.7652 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0407 | 0.0817 |
Plasmodium vivax | phosphatidylinositol 3-kinase, putative | 0.0061 | 0.0034 | 0.5 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0269 | 0.298 | 0.298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0116 | 0.0813 | 0.163 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0411 | 0.4986 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0406 | 0.0814 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0374 | 0.4464 | 0.4464 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0411 | 0.4986 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0143 | 0.1197 | 0.2401 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0269 | 0.298 | 0.298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0152 | 0.1323 | 0.2653 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0061 | 0.0034 | 0.0068 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.007 | 0.0159 | 0.1204 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0411 | 0.4986 | 1 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0143 | 0.1197 | 0.1197 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0374 | 0.4464 | 0.8955 |
Entamoeba histolytica | hypothetical protein | 0.0329 | 0.3823 | 0.7652 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0124 | 0.0917 | 0.184 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0106 | 0.0668 | 0.1339 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0116 | 0.0813 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0132 | 0.1032 | 0.207 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0096 | 0.0522 | 0.1047 |
Giardia lamblia | Kinase, TTK | 0.0374 | 0.4464 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0374 | 0.4464 | 0.8955 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0269 | 0.298 | 0.5977 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0152 | 0.1323 | 0.2653 |
Brugia malayi | Protein kinase domain containing protein | 0.0374 | 0.4464 | 0.8955 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0411 | 0.4986 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0411 | 0.4986 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0096 | 0.0522 | 0.1047 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0683 | 0.8837 | 1 |
Echinococcus multilocularis | Zinc finger, PHD finger | 0.0061 | 0.0034 | 0.0034 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0124 | 0.0916 | 0.1837 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0061 | 0.0034 | 0.0034 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0406 | 0.0814 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0152 | 0.1323 | 0.2653 |
Echinococcus multilocularis | phosphatidylinositol 4 kinase alpha | 0.0061 | 0.0034 | 0.0034 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0152 | 0.1323 | 0.2603 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0407 | 0.0817 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0152 | 0.1323 | 0.1323 |
Leishmania major | phosphatidylinositol 4-kinase alpha, putative | 0.0061 | 0.0034 | 0.0257 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.