Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, TTK | 0.0474 | 0.7778 | 0.5 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0474 | 0.7778 | 0.7778 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0474 | 0.7778 | 0.7778 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0096 | 0.115 | 0.1478 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0474 | 0.7778 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.0618 | 0.0794 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.1674 | 0.2152 |
Loa Loa (eye worm) | TTK protein kinase | 0.0474 | 0.7778 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0096 | 0.115 | 0.1478 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.1674 | 0.2152 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.1674 | 0.2152 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.06 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0618 | 0.0794 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0474 | 0.7778 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0096 | 0.115 | 0.1478 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.115 | 0.1478 |
Schistosoma mansoni | microtubule-associated protein tau | 0.06 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0474 | 0.7778 | 0.5 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0474 | 0.7778 | 0.7778 |
Brugia malayi | Protein kinase domain containing protein | 0.0474 | 0.7778 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0618 | 0.0618 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.