Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | chromatin assembly factor 1 protein WD40 domain, putative | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0237 | 0.1801 | 0.5 | |
Loa Loa (eye worm) | WD domain-containing protein | 0.0293 | 0.2273 | 0.2248 |
Brugia malayi | SET domain containing protein | 0.0484 | 0.3899 | 1 |
Plasmodium falciparum | chromatin assembly factor 1 subunit, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | polycomb protein EED | 0.0293 | 0.2273 | 0.2273 |
Echinococcus multilocularis | histone lysine N methyltransferase E(z) | 0.0484 | 0.3899 | 0.3899 |
Echinococcus granulosus | histone lysine N methyltransferase Ez | 0.0484 | 0.3899 | 0.3899 |
Echinococcus multilocularis | polycomb protein suz12 A | 0.1003 | 0.8299 | 0.8299 |
Toxoplasma gondii | RbAp48 | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | ae-1 binding protein aebp2 | 0.1204 | 1 | 1 |
Schistosoma mansoni | enhancer of zeste ezh | 0.0484 | 0.3899 | 0.3899 |
Plasmodium vivax | chromatin assembly factor 1 P55 subunit, putative | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | WD domain, G-beta repeat-containing protein | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | RbAp46 | 0.0025 | 0 | 0.5 |
Entamoeba histolytica | WD domain containing protein | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1003 | 0.8299 | 0.8299 |
Brugia malayi | WD domain containing protein | 0.0293 | 0.2273 | 0.2248 |
Echinococcus multilocularis | Zinc finger protein jing protein | 0.1204 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Plasmodium vivax | chromatin assembly factor 1 protein WD40 domain, putative | 0.0025 | 0 | 0.5 |
Giardia lamblia | Histone acetyltransferase type B subunit 2 | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | polycomb protein EED | 0.0293 | 0.2273 | 0.2273 |
Schistosoma mansoni | embryonic ectoderm development protein | 0.0293 | 0.2273 | 0.2273 |
Loa Loa (eye worm) | SET domain-containing protein | 0.0484 | 0.3899 | 1 |
Plasmodium vivax | chromatin assembly factor 1 P55 subunit, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | polycomb protein suz12 A | 0.1003 | 0.8299 | 0.8299 |
Plasmodium falciparum | chromatin assembly factor 1 P55 subunit, putative | 0.0025 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.834 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.484 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.36 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.321 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.208 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.056 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.04 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.