Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase domain containing protein | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.9241 | 0.9234 |
Loa Loa (eye worm) | plexin A | 0.0194 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.9241 | 0.9234 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0182 | 0.9241 | 0.9234 |
Schistosoma mansoni | plexin | 0.0164 | 0.8075 | 0.8727 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.9241 | 0.9234 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.1954 | 0.2041 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 0.9241 | 1 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0038 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0069 | 0.1954 | 0.1885 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.1954 | 0.2041 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.3682 | 0.3928 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Echinococcus multilocularis | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Echinococcus multilocularis | semaphorin 5B | 0.0069 | 0.1954 | 0.1885 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 0.9241 | 0.9234 |
Echinococcus granulosus | plexin a4 | 0.0194 | 1 | 1 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0069 | 0.1954 | 0.1885 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 0.9241 | 0.9234 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.3682 | 0.3627 |
Echinococcus multilocularis | plexin a4 | 0.0194 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 0.9241 | 0.9234 |
Onchocerca volvulus | 0.0069 | 0.1954 | 0.2041 | |
Brugia malayi | Sema domain containing protein | 0.0069 | 0.1954 | 0.1885 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 0.9241 | 0.9234 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Echinococcus granulosus | semaphorin 1A | 0.0069 | 0.1954 | 0.1885 |
Onchocerca volvulus | 0.0182 | 0.9241 | 1 | |
Brugia malayi | Sema domain containing protein | 0.0069 | 0.1954 | 0.1885 |
Echinococcus granulosus | semaphorin 5B | 0.0069 | 0.1954 | 0.1885 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 0.9241 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Brugia malayi | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.8075 | 0.8059 |
Brugia malayi | Plexin repeat family protein | 0.0164 | 0.8075 | 0.8059 |
Schistosoma mansoni | semaphorin 5-related | 0.0069 | 0.1954 | 0.2041 |
Brugia malayi | hypothetical protein | 0.0069 | 0.1954 | 0.1885 |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 0.9241 | 0.9234 |
Onchocerca volvulus | 0.0164 | 0.8075 | 0.8727 | |
Schistosoma mansoni | plexin | 0.0096 | 0.3682 | 0.3928 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 0.9241 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.473 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.988 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.954 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.888 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.873 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.82 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.817 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.799 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.78 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.762 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.