Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0769 | 0.0135 | 0.027 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0769 | 0.0135 | 0.027 |
Schistosoma mansoni | choline o-acyltransferase | 0.0689 | 0 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0769 | 0.0135 | 0.0135 |
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0769 | 0.0135 | 0.027 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.3647 | 0.5003 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.3647 | 0.5003 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3647 | 0.5003 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.6601 | 1 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0769 | 0.0135 | 0.027 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.3647 | 0.5003 | 1 |
Onchocerca volvulus | 0.0689 | 0 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3647 | 0.5003 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0769 | 0.0135 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0769 | 0.0135 | 0.0135 |
Schistosoma mansoni | choline o-acyltransferase | 0.0689 | 0 | 0.5 |
Onchocerca volvulus | 0.0689 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.