Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | beta galactosidase | 0.0277 | 0.3732 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.3732 | 0.3618 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0201 | 0.2653 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0079 | 0.0757 | 0.1575 |
Trypanosoma cruzi | glutathionylspermidine synthase, putative | 0.0379 | 0.526 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0201 | 0.2653 |
Leishmania major | trypanothione synthetase, putative | 0.0073 | 0.066 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0201 | 0.2653 |
Schistosoma mansoni | beta-galactosidase | 0.0277 | 0.3732 | 1 |
Trypanosoma cruzi | trypanothione synthetase | 0.0073 | 0.066 | 0.0908 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0079 | 0.0757 | 0.1575 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0079 | 0.0757 | 0.1575 |
Toxoplasma gondii | melibiase subfamily protein | 0.0079 | 0.0757 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0042 | 0.0201 | 0.0022 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0079 | 0.0757 | 0.1575 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0694 | 1 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0042 | 0.0201 | 0.2653 |
Onchocerca volvulus | 0.0042 | 0.0201 | 0.5 | |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0079 | 0.0757 | 0.1575 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0042 | 0.0201 | 0.5 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0079 | 0.0757 | 0.1575 |
Brugia malayi | Melibiase family protein | 0.0079 | 0.0757 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0201 | 0.0022 |
Trypanosoma brucei | trypanothione synthetase | 0.0073 | 0.066 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0201 | 0.2653 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0085 | 0.0839 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0201 | 0.2653 |
Entamoeba histolytica | cyclin, putative | 0.0042 | 0.0201 | 0.5 |
Echinococcus multilocularis | beta galactosidase | 0.0277 | 0.3732 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0079 | 0.0757 | 0.1575 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0201 | 0.2653 |
Trypanosoma brucei | trypanothione synthetase, putative | 0.0073 | 0.066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0757 | 0.0589 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0079 | 0.0757 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.3732 | 0.3618 |
Trypanosoma cruzi | trypanothione synthetase | 0.0073 | 0.066 | 0.0908 |
Plasmodium vivax | hypothetical protein, conserved | 0.0085 | 0.0839 | 0.5 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0079 | 0.0757 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0201 | 0.0022 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0201 | 0.2653 |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0201 | 0.2653 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0042 | 0.0201 | 0.0022 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0079 | 0.0757 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 35 mg kg-1 | Anti-tetrabenazine (TBZ) activity, ability to prevent TBZ-induced ptosis in mice | ChEMBL. | 6471069 |
IC50 (functional) | = 0.57 uM | In vitro inhibition of norepinephrine uptake in rat brain synaptosomes using [3H]-NE | ChEMBL. | 6471069 |
IC50 (functional) | = 0.6 uM | In vitro inhibition of 5-HT uptake in rat brain synaptosomes using [3H]- 5-hydroxytryptamine | ChEMBL. | 6471069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.