TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 429.493 | Formula: C20H23N5O4S
H donors: 2 H acceptors: 5 LogP: 0.36 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCNC(=O)Nc1ccc(cc1)c1nc2CS(=O)(=O)Cc2c(n1)N1C[C@@H]2C[C@H]1CO2
InChi: 1S/C20H23N5O4S/c1-2-21-20(26)22-13-5-3-12(4-6-13)18-23-17-11-30(27,28)10-16(17)19(24-18)25-8-15-7-14(25)9-29-15/h3-6,14-15H,2,7-11H2,1H3,(H2,21,22,26)/t14-,15-/m0/s1
InChiKey: JPOAQDAFYRTLEO-GJZGRUSLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0118	0.1102
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0337	0.4081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0728	0.1303
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0067	0.0119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0322	0.0576
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0337	0.4081
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0118	0.1102
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0118	0.0076
Schistosoma mansoni	pyruvate kinase	0.0033	0.0337	0.0295
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0067	0.0119
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0337	0.0272
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0118	0.1102
Loa Loa (eye worm)	ShTK domain-containing protein	0.056	1	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.056	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0118	0.0052
Onchocerca volvulus		0.056	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0118	0.0052
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0337	0.0602
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0118	0.1102
Loa Loa (eye worm)	ShTK domain-containing protein	0.056	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0118	0.0052
Brugia malayi	steroid hormone receptor	0.0021	0.0118	0.0052
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0118	0.1102
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0118	0.0076
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0067	0.0024
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	0.0728	0.0688
Echinococcus granulosus	pyruvate kinase	0.0033	0.0337	0.4287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0067	0.0119
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0067	0.0349
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0118	0.0052
Leishmania major	pyruvate kinase	0.0033	0.0337	0.4081
Echinococcus multilocularis	pyruvate kinase	0.0026	0.021	0.2432
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0118	0.0052
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0337	0.0221
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	0.5591	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0337	0.0221
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	0.5591	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.027	0.0484
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0118	0.0052
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0118	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0118	0.0052
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0319	0.5591	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0118	0.1102
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0118	0.0052
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0067	0.0349
Entamoeba histolytica	hypothetical protein	0.0039	0.0454	0.0552
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0454	0.0413
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0118	0.0076
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0319	0.5591	1
Schistosoma mansoni	tyrosinase precursor	0.056	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0118	0.1102
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.0473	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0118	0.0076
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0118	0.0076
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0118	0.0076
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0337	0.0272
Brugia malayi	hypothetical protein	0.0039	0.0454	0.039
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0118	0.1102
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0118	0.0052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.027	0.0484
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.0204	0.207
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0337	0.5
Giardia lamblia	Pyruvate kinase	0.0033	0.0337	0.053
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0118	0.0052
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0118	0.0076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0401	0.0717
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0118	0.0052
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.0526	0.6934
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.056	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0118	0.0052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0728	0.1303
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0118	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0337	0.0272
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0473	0.0847
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0322	0.0576
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.027	0.0484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0525	0.0939
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0379	0.0678
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.027	0.0484
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	0.5591	1
Loa Loa (eye worm)	hypothetical protein	0.056	1	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.0728	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0118	0.0076
Giardia lamblia	GTOR	0.0054	0.0728	0.1236
Brugia malayi	nuclear hormone receptor	0.0021	0.0118	0.0052
Brugia malayi	Common central domain of tyrosinase family protein	0.056	1	1
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0337	0.0272
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.056	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0118	0.0076
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0118	0.0052
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.0728	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0118	0.0052
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.0728	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0328	0.0586
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0118	0.0052
Loa Loa (eye worm)	tyrosinase 1	0.056	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.027	0.0482
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	0.5591	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0118	0.1102
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0118	0.0052
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	0.5591	1
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0118	0.1102
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0118	0.0052
Schistosoma mansoni	hypothetical protein	0.0039	0.0454	0.0413
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	0.0728	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0156	0.2594	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0118	0.1102
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0337	1
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0118	0.0052
Loa Loa (eye worm)	hypothetical protein	0.056	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.0728	0.0666
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0118	0.1102
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0118	0.0052
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0118	0.0052
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0118	0.1102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0473	0.0847
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0728	0.1303
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0525	0.0939
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	0.0728	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.0728	1
Onchocerca volvulus		0.056	1	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	0.0728	0.1056
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0118	0.0076
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0337	0.4287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0473	0.0847
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0525	0.0939
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0473	0.0847
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0454	0.5997
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0118	0.0052
Echinococcus granulosus	pyruvate kinase	0.0033	0.0337	0.4287
Schistosoma mansoni	tyrosinase precursor	0.056	1	1
Plasmodium falciparum	pyruvate kinase	0.0033	0.0337	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.027	0.0482
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0156	0.2594	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.0728	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0067	0.0119
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.0728	0.0666
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0454	0.5997
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0337	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0118	0.0052
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0118	0.0052
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	0.5591	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0118	0.0052
Entamoeba histolytica	hypothetical protein	0.0039	0.0454	0.0552
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0473	0.0847
Entamoeba histolytica	hypothetical protein	0.0039	0.0454	0.0552
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0473	0.0847
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0118	0.1102
Onchocerca volvulus		0.056	1	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0118	0.1102
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.056	1	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	0.5591	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.0146	0.1204
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0118	0.0052
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0118	0.1102
Treponema pallidum	fructose-bisphosphate aldolase	0.0319	0.5591	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.027	0.0482
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0118	0.1102
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0118	0.1102
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0118	0.0076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0525	0.0939
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	0.0728	0.1056
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0337	0.4081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0328	0.0586
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0583	0.1043
Brugia malayi	ecdysteroid receptor	0.0021	0.0118	0.0052
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0337	0.0602
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.0526	0.6934
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0154	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0154	0.0088
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0473	0.0847
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0118	0.0052
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0156	0.2594	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0118	0.0052
Schistosoma mansoni	pyruvate kinase	0.0033	0.0337	0.0295
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0525	0.0939
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0118	0.0052
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0118	0.0052
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0118	0.0052
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0337	0.6828
Schistosoma mansoni	coup transcription factor	0.0021	0.0118	0.0076
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0337	0.4081
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.0526	0.6934
Entamoeba histolytica	hypothetical protein	0.0039	0.0454	0.0552
Giardia lamblia	Fructose-bisphosphate aldolase	0.0319	0.5591	1
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0337	0.0272
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0337	0.0272
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0118	0.0076
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.0728	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0067	0.0119
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0337	0.4287
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0118	0.0052
Leishmania major	pyruvate kinase	0.0033	0.0337	0.4081
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	0.5591	1
Onchocerca volvulus		0.056	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0328	0.0586

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1290 nM	Inhibition of mTOR-mediated AKT phosphorylation at Ser473 by cell based assay	ChEMBL.	22765900
Inhibition (binding)	= 3 %	Inhibition of PI3Kalpha at 100 nM	ChEMBL.	22765900
Ki (binding)	= 62 nM	Inhibition of mTOR	ChEMBL.	22765900

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2063761

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1654259