Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.00341892 | 0.137787 | 0.137787 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0032606 | 0.129669 | 0.129669 |
Loa Loa (eye worm) | hypothetical protein | 0.00341892 | 0.137787 | 0.137787 |
Onchocerca volvulus | 0.00341892 | 0.137787 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.00341892 | 0.137787 | 0.137787 |
Loa Loa (eye worm) | carboxylesterase | 0.0202344 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.00341892 | 0.137787 | 0.137787 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.00106597 | 0.0171396 | 0.0171396 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00359487 | 0.146809 | 0.146809 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0032606 | 0.129669 | 0.129669 |
Onchocerca volvulus | 0.00341892 | 0.137787 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0202344 | 1 | 1 |
Onchocerca volvulus | 0.00341892 | 0.137787 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0202344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00341892 | 0.137787 | 0.137787 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00341892 | 0.137787 | 0.137787 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.00106597 | 0.0171396 | 0.0171396 |
Brugia malayi | Carboxylesterase family protein | 0.00341892 | 0.137787 | 0.137787 |
Onchocerca volvulus | 0.00341892 | 0.137787 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00341892 | 0.137787 | 0.137787 |
Loa Loa (eye worm) | hypothetical protein | 0.0202344 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.00341892 | 0.137787 | 0.137787 |
Brugia malayi | hypothetical protein | 0.00341892 | 0.137787 | 0.137787 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.00341892 | 0.137787 | 0.137787 |
Brugia malayi | Carboxylesterase family protein | 0.0202344 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00341892 | 0.137787 | 0.137787 |
Echinococcus multilocularis | voltage gated potassium channel | 0.00106597 | 0.0171396 | 0.0171396 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.00341892 | 0.137787 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00341892 | 0.137787 | 0.137787 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.00341892 | 0.137787 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0202344 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00279841 | 0.10597 | 0.10597 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0202344 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.00341892 | 0.137787 | 0.137787 |
Echinococcus granulosus | neuroligin | 0.00341892 | 0.137787 | 0.137787 |
Schistosoma mansoni | acetylcholinesterase | 0.00341892 | 0.137787 | 0.137787 |
Loa Loa (eye worm) | hypothetical protein | 0.00341892 | 0.137787 | 0.137787 |
Echinococcus granulosus | BC026374 protein S09 family | 0.00341892 | 0.137787 | 0.137787 |
Loa Loa (eye worm) | hypothetical protein | 0.00106597 | 0.0171396 | 0.0171396 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00359487 | 0.146809 | 0.146809 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.00106597 | 0.0171396 | 0.0171396 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0032606 | 0.129669 | 0.129669 |
Loa Loa (eye worm) | hypothetical protein | 0.00341892 | 0.137787 | 0.137787 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.00341892 | 0.137787 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.00341892 | 0.137787 | 0.137787 |
Brugia malayi | Carboxylesterase family protein | 0.00341892 | 0.137787 | 0.137787 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00106597 | 0.0171396 | 0.0171396 |
Loa Loa (eye worm) | carboxylesterase | 0.00341892 | 0.137787 | 0.137787 |
Loa Loa (eye worm) | hypothetical protein | 0.0202344 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.00341892 | 0.137787 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.00341892 | 0.137787 | 0.137787 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0202344 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0202344 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0202344 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.00341892 | 0.137787 | 0.137787 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.00299109 | 0.11585 | 0.840792 |
Loa Loa (eye worm) | hypothetical protein | 0.00341892 | 0.137787 | 0.137787 |
Brugia malayi | Carboxylesterase family protein | 0.00341892 | 0.137787 | 0.137787 |
Loa Loa (eye worm) | carboxylesterase | 0.00341892 | 0.137787 | 0.137787 |
Brugia malayi | Carboxylesterase family protein | 0.00341892 | 0.137787 | 0.137787 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.00299109 | 0.11585 | 0.840792 |
Echinococcus granulosus | carboxylesterase 5A | 0.0202344 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.00341892 | 0.137787 | 0.137787 |
Echinococcus granulosus | voltage gated potassium channel | 0.00106597 | 0.0171396 | 0.0171396 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00106597 | 0.0171396 | 0.0171396 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.00341892 | 0.137787 | 0.5 |
Onchocerca volvulus | 0.00341892 | 0.137787 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.00341892 | 0.137787 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0032606 | 0.129669 | 0.129669 |
Echinococcus granulosus | acetylcholinesterase | 0.0202344 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei 427 (BS221) assessed as increased propidium iodide uptake at 50 to 100 uM after 30 mins by real-time cell lysis assay | ChEMBL. | 24900279 | |
EC50 (functional) | = 1.5 uM | Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 18 hrs by liquid scintillation counting | ChEMBL. | 24900279 |
EC50 (functional) | = 2.3 uM | Antitrypanosomal activity against TbAt1-deficient bloodstraem form of Trypanosoma brucei brucei 427 (BS221) after 72 hrs by alamar blue assay | ChEMBL. | 24900279 |
EC50 (functional) | = 2.3 uM | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei 427 (BS221) after 72 hrs by alamar blue assay | ChEMBL. | 24900279 |
EC50 (functional) | = 2.7 uM | Antileishmanial activity against promastigotes of Leishmania major Friedlin after 72 hrs by alamar blue assay | ChEMBL. | 24900279 |
EC50 (functional) | = 2.7 uM | Antitrypanosomal activity against TbAt1-deficient bloodstraem form Trypanosoma brucei brucei B48 after 72 hrs by alamar blue assay | ChEMBL. | 24900279 |
EC50 (functional) | = 4.8 uM | Antileishmanial activity against amastigotes of Leishmania mexicana MNYC/BZ/62/M379 after 72 hrs by alamar blue assay | ChEMBL. | 24900279 |
EC50 (ADMET) | = 183 uM | Cytotoxicity against human HEK293T cells after 72 hrs by alamar blue assay | ChEMBL. | 24900279 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 24900279 | ||
Plasmodium falciparum | ChEMBL23 | 24900279 | |
Leishmania major | ChEMBL23 | 24900279 | |
Leishmania mexicana | ChEMBL23 | 24900279 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.