Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyl diphosphate synthase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 150 nM | Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 mins prior to substrate addition measured after 10 mins by scintillation counting | ChEMBL. | 22390415 |
IC50 (binding) | = 150 nM | Inhibition of human His6-tagged recombinant FPPS expressed in Escherichia coli BL21(DE3) using GPP and [3H]IPP as substrate incubated for 5 mins prior to substrate addition measured after 20 mins by liquid scintillation counting | ChEMBL. | 22884353 |
Inhibition (binding) | Inhibition of human N-terminal His6-tagged recombinant human GGPS expressed in Escherichia coli BL21(DE3) using FPP and [14C]IPP as substrate at 10 uM by scintillation counting | ChEMBL. | 22884353 | |
Inhibition (binding) | = 85 % | Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate at 1 uM incubated for 10 mins prior to substrate addition measured after 20 mins by liquid scintillation counting | ChEMBL. | 22390415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.