Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carbonic anhydrase | 0.0551 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0352 | 0.3644 | 0.3439 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0352 | 0.3644 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0352 | 0.3644 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0551 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0352 | 0.3644 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0313 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0238 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0238 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0352 | 0.3644 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.0313 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0551 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0312 | 0.2381 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0551 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.537 nM | Inhibition of human carbonic anhydrase-1 | ChEMBL. | 23206986 |
Ki (binding) | = 1.879 nM | Inhibition of human carbonic anhydrase-2 | ChEMBL. | 23206986 |
Ki (binding) | = 3.171 nM | Inhibition of human carbonic anhydrase-12 | ChEMBL. | 23206986 |
Ki (binding) | = 3.429 nM | Inhibition of human carbonic anhydrase-9 | ChEMBL. | 23206986 |
Ki (binding) | = 16 nM | Inhibition of human carbonic anhydrase 9 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 29 nM | Inhibition of human carbonic anhydrase 12 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 568 nM | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Ki (binding) | = 12500 nM | Inhibition of human carbonic anhydrase 1 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay | ChEMBL. | 22721713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.