Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAZ zinc finger family protein | 0.0099 | 0.4849 | 0.4594 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0187 | 1 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0024 | 0.0472 | 0.0472 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0187 | 1 | 1 |
Trypanosoma brucei | N-myristoyltransferase | 0.0187 | 1 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0024 | 0.0472 | 0.0472 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0187 | 1 | 0.5 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0187 | 1 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0024 | 0.0472 | 0.0472 |
Echinococcus granulosus | CREB binding protein | 0.0099 | 0.4849 | 0.4849 |
Schistosoma mansoni | N-myristoyltransferase | 0.0187 | 1 | 1 |
Onchocerca volvulus | 0.0024 | 0.0472 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0.0472 | 0.5 | |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0187 | 1 | 1 |
Echinococcus granulosus | CREB binding protein | 0.0061 | 0.2626 | 0.2626 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0187 | 1 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0187 | 1 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0132 | 0.6809 | 0.6809 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0187 | 1 | 0.5 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0187 | 1 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0132 | 0.6809 | 0.6809 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0187 | 1 | 1 |
Leishmania major | N-myristoyl transferase, putative | 0.0187 | 1 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0132 | 0.6809 | 0.6651 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0132 | 0.6809 | 0.6651 |
Giardia lamblia | CDC72 | 0.0187 | 1 | 0.5 |
Loa Loa (eye worm) | CBP-B | 0.0069 | 0.3077 | 0.2734 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0099 | 0.4849 | 0.4594 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0132 | 0.6809 | 0.6651 |
Echinococcus multilocularis | CREB binding protein | 0.0068 | 0.3027 | 0.3027 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0132 | 0.6809 | 0.6651 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.6809 | 0.6651 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0099 | 0.4849 | 0.4594 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1772 | 0.1364 |
Echinococcus granulosus | choline O acetyltransferase | 0.0024 | 0.0472 | 0.0472 |
Onchocerca volvulus | 0.0024 | 0.0472 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0.0472 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
KA (binding) | = 0.49 uM | Displacement of [3H]-pirenzepine from Muscarinic acetylcholine receptor M1 in rabbit sympathetic ganglia homogenate | ChEMBL. | 1379640 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.