Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor M1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Muscarinic acetylcholine receptor M1 | 460 aa | 462 aa | 23.4 % |
Loa Loa (eye worm) | hypothetical protein | Muscarinic acetylcholine receptor M1 | 460 aa | 425 aa | 22.1 % |
Echinococcus multilocularis | serotonin receptor | Muscarinic acetylcholine receptor M1 | 460 aa | 432 aa | 26.6 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Muscarinic acetylcholine receptor M1 | 460 aa | 432 aa | 26.6 % |
Schistosoma mansoni | amine GPCR | Muscarinic acetylcholine receptor M1 | 460 aa | 463 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0118 | 0.018 | 0.018 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0184 | 0.0484 | 0.0446 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1046 | 0.4446 | 0.5 |
Onchocerca volvulus | 0.0184 | 0.0484 | 1 | |
Brugia malayi | thymidylate synthase | 0.0184 | 0.0484 | 0.0484 |
Brugia malayi | hypothetical protein | 0.0088 | 0.004 | 0.004 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2255 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2255 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0088 | 0.004 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1046 | 0.4446 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.2255 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.2255 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0118 | 0.018 | 0.018 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.0017 | 0.0017 |
Schistosoma mansoni | lipoxygenase | 0.0118 | 0.018 | 0.018 |
Schistosoma mansoni | dihydrofolate reductase | 0.2255 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1046 | 0.4446 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0184 | 0.0484 | 0.0484 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2255 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2255 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1046 | 0.4446 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2255 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0184 | 0.0484 | 0.0484 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0184 | 0.0484 | 0.0484 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2255 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0184 | 0.0484 | 0.0484 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1046 | 0.4446 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1046 | 0.4446 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.36 mM | Tested for stimulating PI(phosphoinositol) hydrolysis in A9L-m1 cells, activity expressed as EC50 mM. | ChEMBL. | 7658434 |
IC50 (binding) | = 2.5 nM | Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-OXO-M as the radioligand. | ChEMBL. | 7658434 |
IC50 (binding) | = 3.7 nM | Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-Pz as the radioligand. | ChEMBL. | 7658434 |
Max (functional) | = 33 % | Stimulating PI (phosphoinositol) hydrolysis in A9L-m1 cells. | ChEMBL. | 7658434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.