Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 4 | Starlite/ChEMBL | References |
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 4 | 303 aa | 312 aa | 29.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0053 | 0 | 0.5 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0053 | 0 | 0.5 |
Brugia malayi | cell division control protein 2 homolog | 0.0053 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0053 | 0 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.268 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.268 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0 | 0.5 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0053 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0053 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0053 | 0 | 0.5 |
Plasmodium vivax | protein kinase Crk2 | 0.0053 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0053 | 0 | 0.5 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0053 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0053 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.268 | 1 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0053 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.268 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0053 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0053 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0053 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0053 | 0 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0053 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0053 | 0 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0053 | 0 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0053 | 0 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase | 0.0053 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0053 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0053 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0 | 0.5 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0053 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.7 uM | Inhibitory concentration against cyclin-dependent kinase 4 | ChEMBL. | 12941312 |
IC50 (binding) | = 0.7 uM | Inhibitory concentration against cyclin-dependent kinase 4 | ChEMBL. | 12941312 |
IC50 (binding) | = 2 uM | Inhibitory concentration against cyclin-dependent kinase 2 | ChEMBL. | 12941312 |
IC50 (binding) | = 2 uM | Inhibitory concentration against cyclin-dependent kinase 2 | ChEMBL. | 12941312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.