Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Candida albicans | beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1546 | 0.1394 |
Mycobacterium ulcerans | glutaminase | 0.0274 | 1 | 0.5 |
Schistosoma mansoni | glutaminase | 0.0274 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0274 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1546 | 0.1546 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1546 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0974 | 0.0974 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0256 | 0.9349 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1546 | 0.1397 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0177 | 0.0453 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1546 | 1 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0974 | 0.6015 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0914 | 0.0754 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0974 | 0.6015 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0112 | 0.0112 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1546 | 0.1546 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1546 | 0.1546 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0177 | 0.0453 |
Onchocerca volvulus | 0.0029 | 0.0914 | 0.5 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.211 | 0.211 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0914 | 0.075 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0974 | 0.0974 |
Loa Loa (eye worm) | glutaminase 2 | 0.0274 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0914 | 0.0914 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1546 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1546 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0274 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.15 ug ml-1 | Inhibition of 1,3-beta-D-glucan synthase in Candida albicans BWP17 membranes | ChEMBL. | 22818082 |
MIC100 (functional) | = 16.7 ug ml-1 | Antifungal activity against Candida albicans C693 by broth dilution method | ChEMBL. | 22818082 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.