Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CYP4Cod1 | 0.0015 | 0.052 | 0.052 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.052 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.4109 | 0.3786 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 0.052 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.2226 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.2487 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0.052 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.2487 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0137 | 0.9702 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.4109 | 0.4109 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.052 | 0.052 |
Brugia malayi | RNA binding protein | 0.0063 | 0.4109 | 0.3786 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.052 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.052 | 0.052 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0.052 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0141 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.4109 | 0.2248 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.2226 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.2487 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0141 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.4109 | 0.3786 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.4109 | 0.4109 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.2487 | 0.5 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.2226 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.4109 | 0.4109 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.2487 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | Agonist activity at Rev-Erbalpha expressed in HEK293 cells coexpressing BamII promoter assessed as repression of transcription after 24 hrs by dual-Glo luciferase assay | ChEMBL. | 22633688 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.