Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 27 (fatty acid transporter), member 1 | Starlite/ChEMBL | References |
Mus musculus | solute carrier family 27 (fatty acid transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | solute carrier family 27 (fatty acid transporter), member 1 | 646 aa | 519 aa | 20.4 % |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | solute carrier family 27 (fatty acid transporter), member 1 | 646 aa | 552 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0238 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0238 | 1 | 1 |
Schistosoma mansoni | FFA transport protein | 0.0224 | 0.9374 | 0.9374 |
Echinococcus granulosus | long chain fatty acid transport protein 4 | 0.0224 | 0.9374 | 0.9374 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0238 | 1 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0238 | 1 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0238 | 1 | 1 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.001 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0221 | 0.9246 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0238 | 1 | 1 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0224 | 0.9374 | 0.9374 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0238 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0238 | 1 | 1 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0231 | 0.9692 | 0.9692 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0238 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0238 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0238 | 1 | 1 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Mycobacterium leprae | possible long-chain acyl-CoA synthase | 0.0221 | 0.9246 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Echinococcus multilocularis | long chain fatty acid transport protein 4 | 0.0224 | 0.9374 | 0.9374 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0238 | 1 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0231 | 0.9692 | 0.9692 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0224 | 0.9374 | 0.9374 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0231 | 0.9692 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0238 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0238 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0238 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0238 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0238 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0238 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0238 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0238 | 1 | 1 |
Leishmania major | fatty acid transporter protein-like protein | 0.0221 | 0.9246 | 0.9246 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1 uM | Inhibition of human recombinant FATP1 acyl-coA synthetase activity using [14C]oleic acid as substrate | ChEMBL. | 22749869 |
IC50 (binding) | = 7.8 uM | Inhibition of mouse recombinant FATP1 acyl-coA synthetase activity using [14C]oleic acid as substrate | ChEMBL. | 22749869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.