Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0151 | 0.6667 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0151 | 0.6667 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0151 | 0.6667 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1165 | 0.1748 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0151 | 0.6667 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1165 | 0.1748 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0151 | 0.6667 | 1 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0151 | 0.6667 | 0.6667 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.013 | 0.5417 | 0.8125 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0151 | 0.6667 | 0.5 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0052 | 0.0669 | 0.5 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0151 | 0.6667 | 0.2665 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0151 | 0.6667 | 0.5 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0151 | 0.6667 | 0.5 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0151 | 0.6667 | 0.5 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0151 | 0.6667 | 0.2665 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0151 | 0.6667 | 1 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0131 | 0.5456 | 0.8184 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0151 | 0.6667 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.005 | 0.0526 | 0.0142 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0151 | 0.6667 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0151 | 0.6667 | 0.5 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0151 | 0.6667 | 0.5 |
Echinococcus multilocularis | geminin | 0.0206 | 1 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0151 | 0.6667 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.5417 | 0.8125 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1165 | 0.1748 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1165 | 0.1748 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.