Detailed information for compound 1669224

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 627.838 | Formula: C33H49N5O5S
  • H donors: 3 H acceptors: 4 LogP: 5.14 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CSCCCCC[C@@H]1NC(=O)[C@H]2CCCCN2CC(=O)[C@@H](NC(=O)[C@@H](NC1=O)Cc1cn(c2c1cccc2)OC)[C@H](CC)C
  • InChi: 1S/C33H49N5O5S/c1-5-22(2)30-29(39)21-37-17-11-10-16-28(37)33(42)34-25(14-7-6-12-18-44-4)31(40)35-26(32(41)36-30)19-23-20-38(43-3)27-15-9-8-13-24(23)27/h8-9,13,15,20,22,25-26,28,30H,5-7,10-12,14,16-19,21H2,1-4H3,(H,34,42)(H,35,40)(H,36,41)/t22-,25-,26-,28+,30-/m0/s1
  • InChiKey: RNAPDEZSTCEZPS-XWNAZLTASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References
Homo sapiens histone deacetylase 7 References
Homo sapiens histone deacetylase 10 References
Homo sapiens histone deacetylase 1 References
Homo sapiens histone deacetylase 8 References
Homo sapiens histone deacetylase 3 References
Homo sapiens histone deacetylase 6 References
Homo sapiens histone deacetylase 2 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum histone deacetylase 1 histone deacetylase 8 286 aa 241 aa 44.8 %
Trypanosoma cruzi histone deacetylase, putative histone deacetylase 3 428 aa 374 aa 30.5 %
Trypanosoma brucei histone deacetylase 2 histone deacetylase 2 488 aa 427 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0291277 0.596319 0.828749
Trypanosoma brucei histone deacetylase, putative 0.0333274 0.688882 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311034 0.639865 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Echinococcus granulosus somatostatin receptor 0.0291277 0.596319 0.585029
Trypanosoma cruzi histone deacetylase 1, putative 0.0311034 0.639865 0.912002
Echinococcus granulosus rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0291277 0.596319 0.585029
Brugia malayi Histone deacetylase family protein 0.0333274 0.688882 1
Echinococcus granulosus histone deacetylase 8 0.0146199 0.27656 0.256327
Brugia malayi ORL1-like opioid receptor 0.0291277 0.596319 0.865633
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0291277 0.596319 0.585029
Onchocerca volvulus 0.0291277 0.596319 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0291277 0.596319 0.585029
Echinococcus multilocularis orexin receptor type 2 0.0291277 0.596319 0.585029
Echinococcus multilocularis neuropeptides capa receptor 0.0291277 0.596319 0.585029
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0291277 0.596319 0.828749
Echinococcus granulosus G protein coupled receptor 139 0.0291277 0.596319 0.585029
Echinococcus multilocularis proteasome (prosome, macropain) 0.0152281 0.289965 0.270107
Schistosoma mansoni adenoreceptor 0.0291277 0.596319 0.828749
Echinococcus granulosus biogenic amine 5HT receptor 0.0291277 0.596319 0.585029
Echinococcus granulosus histone deacetylase 3 0.0311034 0.639865 0.629793
Echinococcus multilocularis histone deacetylase 6 0.0343933 0.712375 0.704331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0291277 0.596319 0.828749
Plasmodium vivax histone deacetylase, putative 0.0333274 0.688882 1
Schistosoma mansoni neuropeptide receptor 0.0291277 0.596319 0.828749
Brugia malayi hypothetical protein 0.0291277 0.596319 0.865633
Brugia malayi Dopamine receptor protein 2 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0152281 0.289965 0.311238
Schistosoma mansoni biogenic amine (5HT) receptor 0.0291277 0.596319 0.828749
Brugia malayi hypothetical protein 0.0291277 0.596319 0.865633
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0152281 0.289965 0.311238
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0291277 0.596319 0.865633
Loa Loa (eye worm) histone deacetylase 0.0333274 0.688882 1
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus granulosus proteasome prosome macropain 0.0152281 0.289965 0.270107
Brugia malayi putative neuropeptide receptor 0.0291277 0.596319 0.865633
Loa Loa (eye worm) G-protein coupled receptor 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0197734 0.390146 0.566346
Brugia malayi Dopamine receptor protein 1 0.0291277 0.596319 0.865633
Echinococcus multilocularis serotonin receptor 0.0291277 0.596319 0.585029
Echinococcus granulosus proteasome prosome macropain subunit beta 0.00805436 0.131853 0.107573
Echinococcus multilocularis histone deacetylase 6 0.0333274 0.688882 0.680181
Schistosoma mansoni opsin-like receptor 0.0291277 0.596319 0.828749
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Schistosoma mansoni histamine h1 receptor 0.0291277 0.596319 0.828749
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Schistosoma mansoni hypothetical protein 0.0291277 0.596319 0.828749
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Plasmodium falciparum histone deacetylase 1 0.0311034 0.639865 0.912002
Echinococcus granulosus neuropeptides capa receptor 0.0291277 0.596319 0.585029
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0291277 0.596319 0.865633
Echinococcus multilocularis neuropeptides capa receptor 0.0291277 0.596319 0.585029
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.00805436 0.131853 0.107573
Echinococcus granulosus histone deacetylase 6 0.0333274 0.688882 0.680181
Echinococcus granulosus neuropeptide receptor 0.0291277 0.596319 0.585029
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus multilocularis histone deacetylase 8 0.0146199 0.27656 0.256327
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus granulosus fmrfamide receptor 0.0291277 0.596319 0.585029
Brugia malayi histone deacetylase 3 (HD3) 0.0311034 0.639865 0.928845
Loa Loa (eye worm) hypothetical protein 0.0187075 0.366653 0.532243
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Brugia malayi RE15519p 0.0291277 0.596319 0.865633
Echinococcus multilocularis neuropeptide Y receptor 0.0291277 0.596319 0.585029
Brugia malayi proteasome subunit beta type 1 0.00805436 0.131853 0.191401
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0291277 0.596319 0.865633
Schistosoma mansoni neuropeptide f receptor 76f 0.0291277 0.596319 0.828749
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0152281 0.289965 0.283849
Onchocerca volvulus 0.0291277 0.596319 1
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0291277 0.596319 0.828749
Echinococcus granulosus neuropeptide receptor A26 0.0291277 0.596319 0.585029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Echinococcus granulosus rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0291277 0.596319 0.585029
Brugia malayi Melatonin receptor type 1A 0.0291277 0.596319 0.865633
Echinococcus multilocularis histone deacetylase 1 0.0311034 0.639865 0.629793
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311034 0.639865 1
Brugia malayi Proteasome A-type and B-type family protein 0.0152281 0.289965 0.420921
Schistosoma mansoni biogenic amine receptor 0.0291277 0.596319 0.828749
Trypanosoma brucei histone deacetylase 2 0.0146199 0.27656 0.259784
Schistosoma mansoni amine GPCR 0.0291277 0.596319 0.828749
Plasmodium falciparum histone deacetylase, putative 0.0333274 0.688882 1
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus granulosus neuropeptide s receptor 0.0291277 0.596319 0.585029
Brugia malayi GnHR receptor homolog 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Schistosoma mansoni amine GPCR 0.0291277 0.596319 0.828749
Trypanosoma cruzi histone deacetylase, putative 0.0333274 0.688882 1
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Brugia malayi hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus multilocularis neuropeptide receptor A26 0.0291277 0.596319 0.585029
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Trichomonas vaginalis histone deacetylase, putative 0.0311034 0.639865 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0291277 0.596319 0.828749
Brugia malayi G protein-coupled receptor 0.0291277 0.596319 0.865633
Plasmodium vivax proteasome subunit beta type-5, putative 0.0152281 0.289965 0.283849
Brugia malayi hypothetical protein 0.0291277 0.596319 0.865633
Onchocerca volvulus 0.0291277 0.596319 1
Entamoeba histolytica histone deacetylase, putative 0.0311034 0.639865 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0291277 0.596319 0.828749
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0291277 0.596319 0.585029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0291277 0.596319 0.828749
Loa Loa (eye worm) histone deacetylase 3 0.0311034 0.639865 0.928845
Echinococcus granulosus tm gpcr rhodopsin 0.0291277 0.596319 0.585029
Onchocerca volvulus 0.0291277 0.596319 1
Echinococcus multilocularis G protein coupled receptor 139 0.0291277 0.596319 0.585029
Brugia malayi Serotonin receptor 0.0291277 0.596319 0.865633
Trypanosoma cruzi histone deacetylase, putative 0.0333274 0.688882 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0291277 0.596319 0.585029
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0474431 1 1
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Onchocerca volvulus Neuropeptide F receptor homolog 0.0291277 0.596319 1
Schistosoma mansoni hypothetical protein 0.0291277 0.596319 0.828749
Brugia malayi hypothetical protein 0.0291277 0.596319 0.865633
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0291277 0.596319 0.865633
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0291277 0.596319 0.828749
Trypanosoma brucei histone deacetylase 4 0.0333274 0.688882 1
Echinococcus multilocularis g protein coupled receptor 0.0291277 0.596319 0.585029
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0291277 0.596319 0.585029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0291277 0.596319 0.828749
Mycobacterium ulcerans proteasome PrcB 0.0152281 0.289965 0.5
Trichomonas vaginalis histone deacetylase, putative 0.0311034 0.639865 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0152281 0.289965 0.283849
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0152281 0.289965 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0291277 0.596319 0.828749
Schistosoma mansoni histone deacetylase 4 5 0.0333274 0.688882 0.965334
Schistosoma mansoni myosin xvIII 0.0291277 0.596319 0.828749
Echinococcus granulosus rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Echinococcus granulosus allatostatin A receptor 0.0291277 0.596319 0.585029
Echinococcus multilocularis fmrfamide receptor 0.0291277 0.596319 0.585029
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0291277 0.596319 0.585029
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0291277 0.596319 0.828749
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0152281 0.289965 0.420921
Echinococcus granulosus g protein coupled receptor 0.0291277 0.596319 0.585029
Echinococcus granulosus peptide allatostatin:somatostatin 0.0291277 0.596319 0.585029
Schistosoma mansoni histone deacetylase 0.0311034 0.639865 0.893005
Echinococcus granulosus neuropeptides capa receptor 0.0291277 0.596319 0.585029
Brugia malayi hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00330645 0.0272065 0.0394937
Onchocerca volvulus 0.0291277 0.596319 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0291277 0.596319 0.828749
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0291277 0.596319 0.585029
Schistosoma mansoni biogenic amine receptor 0.0291277 0.596319 0.828749
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus granulosus histone deacetylase 0.0333274 0.688882 0.680181
Plasmodium vivax histone deacetylase, putative 0.0146199 0.27656 0.259784
Loa Loa (eye worm) histone deacetylase 1 0.0311034 0.639865 0.928845
Schistosoma mansoni growth hormone secretagogue receptor 0.0291277 0.596319 0.828749
Echinococcus multilocularis rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Schistosoma mansoni alpha-1 adrenergic receptor 0.0291277 0.596319 0.828749
Brugia malayi hypothetical protein 0.0291277 0.596319 0.865633
Onchocerca volvulus 0.0291277 0.596319 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0291277 0.596319 0.585029
Echinococcus granulosus histone deacetylase 7 0.0333274 0.688882 0.680181
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0291277 0.596319 0.585029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Echinococcus granulosus histone deacetylase 1 0.0311034 0.639865 0.629793
Schistosoma mansoni opsin-like receptor 0.0291277 0.596319 0.828749
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0291277 0.596319 0.865633
Loa Loa (eye worm) melatonin receptor type 1A 0.0291277 0.596319 0.865633
Brugia malayi hypothetical protein 0.0291277 0.596319 0.865633
Leishmania major histone deacetylase, putative 0.0311034 0.639865 0.912002
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus granulosus orexin receptor type 2 0.0291277 0.596319 0.585029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0291277 0.596319 0.828749
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0291277 0.596319 0.865633
Leishmania major histone deacetylase, putative 0.0333274 0.688882 1
Brugia malayi neuropeptide F receptor 0.0291277 0.596319 0.865633
Onchocerca volvulus 0.0291277 0.596319 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0291277 0.596319 0.865633
Schistosoma mansoni neuropeptide F-like receptor 0.0291277 0.596319 0.828749
Echinococcus multilocularis rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Schistosoma mansoni hypothetical protein 0.0291277 0.596319 0.828749
Brugia malayi sulfakinin receptor protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) neuropeptide F receptor 0.0291277 0.596319 0.865633
Schistosoma mansoni histone deacetylase hda2 0.0146199 0.27656 0.356918
Schistosoma mansoni neuropeptide receptor 0.0291277 0.596319 0.828749
Echinococcus multilocularis g protein coupled receptor 0.0291277 0.596319 0.585029
Brugia malayi histone deacetylase 1 (HD1) 0.0311034 0.639865 0.928845
Brugia malayi G-protein coupled receptor 0.0291277 0.596319 0.865633
Schistosoma mansoni opsin-like receptor 0.0291277 0.596319 0.828749
Brugia malayi G-protein coupled receptor 0.0291277 0.596319 0.865633
Echinococcus granulosus hypothetical protein 0.0291277 0.596319 0.585029
Echinococcus multilocularis histone deacetylase 0.0333274 0.688882 0.680181
Echinococcus granulosus g protein coupled receptor 0.0291277 0.596319 0.585029
Trypanosoma cruzi histone deacetylase, putative 0.0333274 0.688882 1
Echinococcus granulosus neuropeptide receptor 0.0291277 0.596319 0.585029
Loa Loa (eye worm) G-protein coupled receptor 0.0291277 0.596319 0.865633
Echinococcus granulosus tachykinin peptides receptor 99D 0.0474431 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Echinococcus granulosus rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Trypanosoma brucei histone deacetylase 3 0.0333274 0.688882 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Echinococcus multilocularis dro:myosuppressin receptor 0.0291277 0.596319 0.585029
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0291277 0.596319 0.585029
Onchocerca volvulus 0.0291277 0.596319 1
Echinococcus multilocularis neuropeptide receptor 0.0291277 0.596319 0.585029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Schistosoma mansoni neuropeptide F-like receptor 0.0291277 0.596319 0.828749
Echinococcus multilocularis fmrfamide receptor 0.0291277 0.596319 0.585029
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0291277 0.596319 1
Echinococcus multilocularis histone deacetylase 3 0.0311034 0.639865 0.629793
Schistosoma mansoni amine GPCR 0.0291277 0.596319 0.828749
Toxoplasma gondii histone deacetylase HDAC5 0.0146199 0.27656 0.259784
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0291277 0.596319 0.585029
Schistosoma mansoni histone deacetylase 4 5 0.0333274 0.688882 0.965334
Echinococcus granulosus biogenic amine 5HT receptor 0.0291277 0.596319 0.585029
Schistosoma mansoni amine GPCR 0.0291277 0.596319 0.828749
Toxoplasma gondii histone deacetylase HDAC2 0.0311034 0.639865 0.912002
Brugia malayi Histone deacetylase family protein 0.0333274 0.688882 1
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Toxoplasma gondii histone deacetylase HDAC3 0.0311034 0.639865 0.912002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0291277 0.596319 0.585029
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0291277 0.596319 0.865633
Onchocerca volvulus 0.0291277 0.596319 1
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0291277 0.596319 0.828749
Echinococcus multilocularis sex peptide receptor 0.0291277 0.596319 0.585029
Trypanosoma brucei histone deacetylase 1 0.0311034 0.639865 0.912002
Schistosoma mansoni hypothetical protein 0.0291277 0.596319 0.828749
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00330645 0.0272065 0.0394937
Onchocerca volvulus 0.0291277 0.596319 1
Leishmania major histone deacetylase, putative 0.0311034 0.639865 0.912002
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0291277 0.596319 0.828749
Plasmodium vivax histone deacetylase 1, putative 0.0311034 0.639865 0.912002
Onchocerca volvulus 0.0291277 0.596319 1
Onchocerca volvulus 0.0291277 0.596319 1
Trichomonas vaginalis histone deacetylase, putative 0.0311034 0.639865 1
Schistosoma mansoni histone deacetylase 1 2 3 0.0146199 0.27656 0.356918
Trichomonas vaginalis histone deacetylase, putative 0.0311034 0.639865 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0291277 0.596319 0.585029
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0291277 0.596319 0.585029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0291277 0.596319 0.828749
Echinococcus granulosus tm gpcr rhodopsin 0.0291277 0.596319 0.585029
Echinococcus multilocularis somatostatin receptor 0.0291277 0.596319 0.585029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0291277 0.596319 0.828749
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.00283776 0.0168763 0.0244981
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0291277 0.596319 0.828749
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0291277 0.596319 0.828749
Brugia malayi putative neuropeptide receptor NPR1 0.0291277 0.596319 0.865633
Echinococcus granulosus serotonin receptor 0.0291277 0.596319 0.585029
Echinococcus granulosus tm gpcr rhodopsin 0.0291277 0.596319 0.585029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0291277 0.596319 0.828749
Echinococcus granulosus dro:myosuppressin receptor 0.0291277 0.596319 0.585029
Plasmodium vivax histone deacetylase 2, putative 0.0333274 0.688882 1
Echinococcus granulosus g-protein coupled receptor 0.0291277 0.596319 0.585029
Brugia malayi histone deacetylase 11 0.0146199 0.27656 0.401462
Trypanosoma cruzi histone deacetylase, putative 0.0146199 0.27656 0.259784
Echinococcus multilocularis neuropeptide s receptor 0.0291277 0.596319 0.585029
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0291277 0.596319 0.865633
Echinococcus granulosus g protein coupled receptor 0.0291277 0.596319 0.585029
Echinococcus granulosus neuropeptide Y receptor 0.0291277 0.596319 0.585029
Echinococcus multilocularis neuropeptide Y receptor 0.0291277 0.596319 0.585029
Echinococcus multilocularis serotonin receptor 0.0291277 0.596319 0.585029
Brugia malayi neuropeptide F receptor 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0291277 0.596319 0.828749
Echinococcus multilocularis g protein coupled receptor 0.0291277 0.596319 0.585029
Echinococcus multilocularis allatostatin A receptor 0.0291277 0.596319 0.585029
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0291277 0.596319 0.585029
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.00805436 0.131853 0.14339
Brugia malayi hypothetical protein 0.0291277 0.596319 0.865633
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0311034 0.639865 1
Loa Loa (eye worm) hypothetical protein 0.0311034 0.639865 0.928845
Echinococcus multilocularis rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus granulosus neuropeptide Y receptor 0.0291277 0.596319 0.585029
Brugia malayi AKH receptor 0.0291277 0.596319 0.865633
Echinococcus granulosus sex peptide receptor 0.0291277 0.596319 0.585029
Plasmodium falciparum proteasome subunit beta type-5 0.0152281 0.289965 0.283849
Toxoplasma gondii histone deacetylase HDAC4 0.0146199 0.27656 0.259784
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0291277 0.596319 0.828749
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0152281 0.289965 0.283849
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0291277 0.596319 0.828749
Trypanosoma cruzi histone deacetylase, putative 0.0146199 0.27656 0.259784
Schistosoma mansoni neuropeptide receptor 0.0291277 0.596319 0.828749
Plasmodium falciparum histone deacetylase 2 0.0333274 0.688882 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0152281 0.289965 0.434443
Echinococcus multilocularis histone deacetylase 6 0.0333274 0.688882 0.680181
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.00805436 0.131853 0.17888
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) proteasome subunit beta type 1 0.00805436 0.131853 0.191401
Leishmania major histone deacetylase, putative 0.0333274 0.688882 1
Brugia malayi hypothetical protein 0.0291277 0.596319 0.865633
Onchocerca volvulus 0.0291277 0.596319 1
Echinococcus granulosus histone deacetylase 6 0.0333274 0.688882 0.680181
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) histone deacetylase 11 0.0146199 0.27656 0.401462
Onchocerca volvulus 0.0291277 0.596319 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0291277 0.596319 0.585029
Echinococcus multilocularis histone deacetylase 7 0.0333274 0.688882 0.680181
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Toxoplasma gondii histone deacetylase HDAC1 0.0333274 0.688882 1
Onchocerca volvulus 0.0291277 0.596319 1
Trichomonas vaginalis histone deacetylase, putative 0.0311034 0.639865 1
Leishmania major proteasome beta 5 subunit, putative 0.0152281 0.289965 0.283849
Loa Loa (eye worm) neuropeptide F receptor 0.0291277 0.596319 0.865633
Echinococcus granulosus neuropeptide FF receptor 2 0.0291277 0.596319 0.585029
Schistosoma mansoni biogenic amine receptor 0.0291277 0.596319 0.828749
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) histone deacetylase 7A 0.0333274 0.688882 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0291277 0.596319 0.865633
Schistosoma mansoni amine GPCR 0.0291277 0.596319 0.828749
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Echinococcus granulosus alpha 1A adrenergic receptor 0.0291277 0.596319 0.585029
Echinococcus granulosus histone deacetylase 6 0.0343933 0.712375 0.704331
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0152281 0.289965 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0291277 0.596319 0.585029
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0291277 0.596319 0.585029
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Brugia malayi Dopamine receptor 0.0291277 0.596319 0.865633
Giardia lamblia Histone deacetylase 0.0311034 0.639865 1
Brugia malayi larval opioid receptor 0.0291277 0.596319 0.865633
Echinococcus multilocularis rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Brugia malayi Serotonin receptor 0.0291277 0.596319 0.865633
Schistosoma mansoni neuropeptide receptor 0.0291277 0.596319 0.828749
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0152281 0.289965 0.376698
Echinococcus granulosus 7TM GPCR rhodopsin 0.0291277 0.596319 0.585029
Loa Loa (eye worm) TYRA-2 protein 0.0291277 0.596319 0.865633
Schistosoma mansoni histone deacetylase 0.0311034 0.639865 0.893005
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Schistosoma mansoni histone deacetylase hda2 0.0343933 0.712375 1
Onchocerca volvulus 0.0291277 0.596319 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0291277 0.596319 0.585029
Brugia malayi follicle stimulating hormone receptor 0.0291277 0.596319 0.865633
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0291277 0.596319 0.585029
Onchocerca volvulus 0.0291277 0.596319 1
Loa Loa (eye worm) hypothetical protein 0.0291277 0.596319 0.865633
Trypanosoma cruzi histone deacetylase 1, putative 0.0311034 0.639865 0.912002
Brugia malayi G protein-coupled receptor F59B2.13 0.0291277 0.596319 0.865633
Loa Loa (eye worm) hypothetical protein 0.0146199 0.27656 0.401462
Echinococcus multilocularis neuropeptide receptor 0.0291277 0.596319 0.585029
Toxoplasma gondii proteasome subunit beta type, putative 0.0152281 0.289965 0.283849
Echinococcus granulosus rhodopsin orphan GPCR 0.0291277 0.596319 0.585029
Brugia malayi Histone deacetylase 1 0.0311034 0.639865 0.928845
Echinococcus multilocularis G-protein coupled receptor, putative 0.0291277 0.596319 0.585029
Trichomonas vaginalis histone deacetylase, putative 0.0311034 0.639865 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 1000 ng ml-1 In vitro antiprotozoal activity (functional assay) using whole red blood cells infected with Plasmodium falciparum ChEMBL. 11206438
IC50 (binding) = 326 nM Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cells ChEMBL. 11206438

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 11206438

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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