Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus multilocularis | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus granulosus | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma japonicum | ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma mansoni | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Abnormal catecholamine distribution protein 1 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | 532 aa | 504 aa | 34.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0372 | 0.0161 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2362 | 0.5668 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0372 | 0.0415 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0215 | 0.0537 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0372 | 0.0161 |
Brugia malayi | hypothetical protein | 0.0161 | 0.2261 | 0.5649 |
Brugia malayi | hypoxia-induced factor 1 | 0.0148 | 0.2058 | 0.5141 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2362 | 0.5668 |
Brugia malayi | bHLH-PAS transcription factor | 0.0035 | 0.0215 | 0.0538 |
Mycobacterium ulcerans | putative regulatory protein | 0.0035 | 0.0215 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0215 | 0.5 |
Schistosoma mansoni | single-minded | 0.0048 | 0.0419 | 0.0538 |
Echinococcus granulosus | geminin | 0.0167 | 0.2362 | 0.2194 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.2261 | 0.5649 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 0.4003 | 0.3871 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 0.4003 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.4003 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0215 | 0.5 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0148 | 0.2058 | 0.5141 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0372 | 0.0415 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0048 | 0.0419 | 0.0538 |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.0419 | 0.1046 |
Echinococcus multilocularis | geminin | 0.0167 | 0.2362 | 0.2194 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0215 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0372 | 0.0929 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 0.4003 | 0.3871 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0372 | 0.0161 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0372 | 0.0415 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0372 | 0.0929 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 0.4003 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0372 | 0.0161 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.4003 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0215 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2000 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.