Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0081 | 0.0769 | 0.0674 |
Brugia malayi | jmjC domain containing protein | 0.0116 | 0.1268 | 0.1139 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0116 | 0.1268 | 0.1139 |
Brugia malayi | mbt repeat family protein | 0.0388 | 0.5147 | 1 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0097 | 0.0991 | 0.1527 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0079 | 0.0735 | 0.064 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0442 | 0.5924 | 1 |
Echinococcus multilocularis | chromobox protein 2 | 0.0167 | 0.1996 | 0.3253 |
Schistosoma mansoni | hypothetical protein | 0.0278 | 0.3573 | 0.3507 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0097 | 0.0991 | 0.1527 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0388 | 0.5147 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0081 | 0.0769 | 0.1147 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0226 | 0.2828 | 0.4682 |
Brugia malayi | mbt repeat family protein | 0.0235 | 0.2959 | 0.5001 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0278 | 0.3573 | 0.5962 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0226 | 0.2828 | 0.2754 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.5147 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0327 | 0.4271 | 0.7161 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0327 | 0.4271 | 0.4212 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0442 | 0.5924 | 1 |
Toxoplasma gondii | PLU-1 family protein | 0.0037 | 0.014 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0235 | 0.2959 | 0.5001 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0066 | 0.0547 | 0.0766 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0226 | 0.2828 | 0.2754 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0081 | 0.0769 | 0.1147 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0081 | 0.0769 | 0.1147 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0327 | 0.4271 | 0.7161 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0226 | 0.2828 | 0.4682 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0079 | 0.0735 | 0.1089 |
Echinococcus granulosus | chromobox protein 2 | 0.0167 | 0.1996 | 0.3253 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0278 | 0.3573 | 0.5962 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0081 | 0.0769 | 0.1147 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0079 | 0.0735 | 0.064 |
Schistosoma mansoni | chromobox protein | 0.0167 | 0.1996 | 0.1914 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 38 uM | Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay | ChEMBL. | 22940705 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.