Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0442 | 0.5924 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0079 | 0.0735 | 0.064 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0097 | 0.0991 | 0.1527 |
Brugia malayi | mbt repeat family protein | 0.0388 | 0.5147 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0081 | 0.0769 | 0.0674 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0116 | 0.1268 | 0.1139 |
Brugia malayi | jmjC domain containing protein | 0.0116 | 0.1268 | 0.1139 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0388 | 0.5147 | 1 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0097 | 0.0991 | 0.1527 |
Schistosoma mansoni | hypothetical protein | 0.0278 | 0.3573 | 0.3507 |
Echinococcus multilocularis | chromobox protein 2 | 0.0167 | 0.1996 | 0.3253 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0226 | 0.2828 | 0.2754 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0278 | 0.3573 | 0.5962 |
Brugia malayi | mbt repeat family protein | 0.0235 | 0.2959 | 0.5001 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0226 | 0.2828 | 0.4682 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0081 | 0.0769 | 0.1147 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0442 | 0.5924 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0327 | 0.4271 | 0.4212 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.5147 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0327 | 0.4271 | 0.7161 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0066 | 0.0547 | 0.0766 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0235 | 0.2959 | 0.5001 |
Toxoplasma gondii | PLU-1 family protein | 0.0037 | 0.014 | 1 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0226 | 0.2828 | 0.4682 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0079 | 0.0735 | 0.1089 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0327 | 0.4271 | 0.7161 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0081 | 0.0769 | 0.1147 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0081 | 0.0769 | 0.1147 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0226 | 0.2828 | 0.2754 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0278 | 0.3573 | 0.5962 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0081 | 0.0769 | 0.1147 |
Echinococcus granulosus | chromobox protein 2 | 0.0167 | 0.1996 | 0.3253 |
Schistosoma mansoni | chromobox protein | 0.0167 | 0.1996 | 0.1914 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0079 | 0.0735 | 0.064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antiallergic activity in IgE/Ag-induced passive cutaneous anaphylactic ICR mouse model injected with DNP-HSA-Evans blue dye post DNP-IgE challenge at 50 to 100 mg/kg, po 1 hr before antigenic challenge measured after 2 hrs post IgE/Ag challenge | ChEMBL. | 22770426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.