Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0129 | 1 | 1 |
Brugia malayi | Reprolysin | 0.0084 | 0.4702 | 0.5867 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0129 | 1 | 1 |
Echinococcus multilocularis | adam | 0.0106 | 0.7266 | 0.5245 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4251 | 0.4126 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0111 | 0.7865 | 0.219 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0111 | 0.7865 | 0.7865 |
Loa Loa (eye worm) | disintegrin family protein | 0.0066 | 0.2567 | 0.2405 |
Echinococcus granulosus | adam | 0.0106 | 0.7266 | 0.7266 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.008 | 0.4251 | 0.4251 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.3325 | 0.3181 |
Brugia malayi | hypothetical protein | 0.0106 | 0.7266 | 0.9218 |
Brugia malayi | Disintegrin family protein | 0.0111 | 0.7865 | 1 |
Loa Loa (eye worm) | reprolysin | 0.0129 | 1 | 1 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0111 | 0.7865 | 0.6286 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0129 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20.1 uM | Inhibition of FAAH in rat brain homogenates pre-incubated for 10 mins before addition of [3H]anandamide and [3H]AEA substrates for 30 mins by liquid scintillation counting | ChEMBL. | 23043222 |
IC50 (binding) | > 100 uM | Inhibition of human COX2 pre-incubated for 10 mins before substrate addition by enzyme immunoassay | ChEMBL. | 23043222 |
IC50 (binding) | > 100 uM | Inhibition of ovine COX1 pre-incubated for 10 mins before arachidonic acid substrate addition by enzyme immunoassay | ChEMBL. | 23043222 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.