Detailed information for compound 1681867

Basic information

Technical information
  • TDR Targets ID: 1681867
  • Name: AIDS-191966
  • MW: 275.369 | Formula: C14H17N3OS
  • H donors: 2 H acceptors: 0 LogP: 1.68 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@@H]1CSCON2[C@H]1c1[nH]c3c(c1CC2)cccc3
  • InChi: 1S/C14H17N3OS/c15-11-7-19-8-18-17-6-5-10-9-3-1-2-4-12(9)16-13(10)14(11)17/h1-4,11,14,16H,5-8,15H2/t11-,14-/m1/s1
  • InChiKey: SFAMFXNCPDEYGA-BXUZGUMPSA-N  


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Synonyms

  • AIDS191966
  • [1,6,2]Oxathiazepino[2',3':1,2]pyrido[3,4-b]indol-1-amine, 1,2,7,8,13,13b-hexahydro-, (1S,13bR)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus G protein coupled receptor 139 0.028 1 1
Brugia malayi Melatonin receptor type 1A 0.028 1 1
Giardia lamblia Cathepsin B precursor 0.0067 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.028 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.028 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.028 1 1
Brugia malayi neuropeptide F receptor 0.028 1 1
Schistosoma mansoni hypothetical protein 0.028 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0185 0.5529 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0072 0.0242 0.5
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Echinococcus granulosus orexin receptor type 2 0.028 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.028 1 1
Echinococcus granulosus neuropeptide receptor 0.028 1 1
Schistosoma mansoni amine GPCR 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0185 0.5529 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.028 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.028 1 1
Echinococcus granulosus g protein coupled receptor 0.028 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.028 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.028 1 1
Plasmodium vivax vivapain-2 0.0072 0.0242 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.028 1 1
Brugia malayi follicle stimulating hormone receptor 0.028 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.028 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0185 0.5529 1
Schistosoma mansoni biogenic amine receptor 0.028 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.028 1 1
Echinococcus multilocularis allatostatin A receptor 0.028 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0072 0.0242 0.5
Loa Loa (eye worm) hypothetical protein 0.0177 0.5169 0.5169
Schistosoma mansoni biogenic amine (5HT) receptor 0.028 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.028 1 1
Schistosoma mansoni adenoreceptor 0.028 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0242 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0185 0.5529 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0185 0.5529 1
Brugia malayi hypothetical protein 0.028 1 1
Brugia malayi G-protein coupled receptor 0.028 1 1
Echinococcus granulosus cathepsin b 0.0177 0.5169 0.5049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Echinococcus granulosus biogenic amine 5HT receptor 0.028 1 1
Echinococcus multilocularis cathepsin b 0.0177 0.5169 0.5049
Leishmania major cathepsin L-like protease 0.0072 0.0242 0.0438
Schistosoma mansoni hypothetical protein 0.028 1 1
Echinococcus multilocularis g protein coupled receptor 0.028 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.028 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0242 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Onchocerca volvulus 0.028 1 1
Echinococcus multilocularis g protein coupled receptor 0.028 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.028 1 1
Brugia malayi ORL1-like opioid receptor 0.028 1 1
Onchocerca volvulus 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0242 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.028 1 1
Loa Loa (eye worm) fibroinase 0.0072 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni biogenic amine receptor 0.028 1 1
Leishmania major cathepsin L-like protease 0.0072 0.0242 0.0438
Echinococcus granulosus tm gpcr rhodopsin 0.028 1 1
Echinococcus granulosus neuropeptide receptor A26 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0185 0.5529 1
Echinococcus multilocularis neuropeptides capa receptor 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Brugia malayi putative neuropeptide receptor 0.028 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.028 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.028 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Brugia malayi hypothetical protein 0.028 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.028 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.028 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0242 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Onchocerca volvulus 0.028 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.028 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.028 1 1
Brugia malayi hypothetical protein 0.028 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.028 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0163 0.4493 0.8125
Schistosoma mansoni amine GPCR 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Loa Loa (eye worm) neuropeptide F receptor 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0242 0.0242
Brugia malayi putative neuropeptide receptor NPR1 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0242 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.028 1 1
Leishmania major cathepsin L-like protease 0.0185 0.5529 1
Loa Loa (eye worm) melatonin receptor type 1A 0.028 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.028 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.028 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.028 1 1
Echinococcus granulosus g protein coupled receptor 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0072 0.0242 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.028 1 1
Plasmodium vivax vivapain-2 0.0072 0.0242 0.5
Echinococcus multilocularis fmrfamide receptor 0.028 1 1
Loa Loa (eye worm) ctsf protein 0.0072 0.0242 0.0242
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.028 1 1
Echinococcus multilocularis g-protein coupled receptor 0.028 1 1
Brugia malayi Serotonin receptor 0.028 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus granulosus allatostatin A receptor 0.028 1 1
Onchocerca volvulus 0.028 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0185 0.5529 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0242 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Onchocerca volvulus 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0072 0.0242 0.0242
Brugia malayi Serotonin receptor 0.028 1 1
Echinococcus multilocularis serotonin receptor 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.028 1 1
Echinococcus granulosus cathepsin b 0.0177 0.5169 0.5049
Onchocerca volvulus 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.028 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.028 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0185 0.5529 1
Brugia malayi AKH receptor 0.028 1 1
Loa Loa (eye worm) TYRA-2 protein 0.028 1 1
Echinococcus multilocularis neuropeptide receptor 0.028 1 1
Echinococcus multilocularis cathepsin b 0.0177 0.5169 0.5049
Brugia malayi neuropeptide F receptor 0.028 1 1
Echinococcus granulosus neuropeptide s receptor 0.028 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.028 1 1
Brugia malayi Dopamine receptor protein 2 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.028 1 1
Brugia malayi G protein-coupled receptor 0.028 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.028 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.028 1 1
Onchocerca volvulus 0.028 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0185 0.5529 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.028 1 1
Echinococcus granulosus neuropeptide Y receptor 0.028 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.028 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0185 0.5529 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Leishmania major cathepsin L-like protease 0.0072 0.0242 0.0438
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Brugia malayi GnHR receptor homolog 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.028 1 1
Schistosoma mansoni histamine h1 receptor 0.028 1 1
Schistosoma mansoni neuropeptide receptor 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0242 1
Echinococcus multilocularis fmrfamide receptor 0.028 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.028 1 1
Brugia malayi Dopamine receptor 0.028 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0072 0.0242 0.0242
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0177 0.5169 0.5169
Echinococcus multilocularis rhodopsin orphan GPCR 0.028 1 1
Onchocerca volvulus 0.028 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.028 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0072 0.0242 0.5
Schistosoma mansoni neuropeptide receptor 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0242 1
Onchocerca volvulus 0.028 1 1
Echinococcus granulosus neuropeptide Y receptor 0.028 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.028 1 1
Echinococcus granulosus sex peptide receptor 0.028 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.013 0.2972 0.5375
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.028 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.028 1 1
Schistosoma mansoni myosin xvIII 0.028 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.028 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0185 0.5529 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.028 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.028 1 1
Onchocerca volvulus 0.028 1 1
Entamoeba histolytica cysteine protease, putative 0.0072 0.0242 0.5
Leishmania major cathepsin L-like protease 0.0072 0.0242 0.0438
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0072 0.0242 0.5
Echinococcus granulosus g protein coupled receptor 0.028 1 1
Onchocerca volvulus 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Brugia malayi hypothetical protein 0.028 1 1
Echinococcus granulosus serotonin receptor 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.028 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.028 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.028 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.028 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.028 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.028 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Brugia malayi hypothetical protein 0.028 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.028 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0072 0.0242 0.0242
Echinococcus granulosus fmrfamide receptor 0.028 1 1
Echinococcus multilocularis g protein coupled receptor 0.028 1 1
Leishmania major cathepsin L-like protease 0.0185 0.5529 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0072 0.0242 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.028 1 1
Schistosoma mansoni opsin-like receptor 0.028 1 1
Brugia malayi hypothetical protein 0.028 1 1
Schistosoma mansoni hypothetical protein 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.028 1 1
Echinococcus granulosus neuropeptides capa receptor 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0177 0.5169 0.5169
Schistosoma mansoni growth hormone secretagogue receptor 0.028 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Onchocerca volvulus 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0242 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni neuropeptide receptor 0.028 1 1
Echinococcus granulosus neuropeptide receptor 0.028 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus multilocularis neuropeptide s receptor 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni amine GPCR 0.028 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.028 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.028 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.028 1 1
Leishmania major cysteine peptidase A (CPA) 0.0072 0.0242 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Echinococcus granulosus rhodopsin orphan GPCR 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0072 0.0242 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.028 1 1
Brugia malayi hypothetical protein 0.028 1 1
Echinococcus granulosus neuropeptides capa receptor 0.028 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.028 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.028 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0185 0.5529 1
Onchocerca volvulus 0.028 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.028 1 1
Schistosoma mansoni opsin-like receptor 0.028 1 1
Schistosoma mansoni amine GPCR 0.028 1 1
Giardia lamblia Cathepsin B precursor 0.0067 0 0.5
Onchocerca volvulus 0.028 1 1
Leishmania major cathepsin L-like protease 0.0185 0.5529 1
Echinococcus granulosus rhodopsin orphan GPCR 0.028 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.028 1 1
Brugia malayi sulfakinin receptor protein 0.028 1 1
Echinococcus multilocularis serotonin receptor 0.028 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.028 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0185 0.5529 1
Brugia malayi RE15519p 0.028 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.028 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.028 1 1
Echinococcus granulosus hypothetical protein 0.028 1 1
Onchocerca volvulus 0.028 1 1
Echinococcus granulosus somatostatin receptor 0.028 1 1
Onchocerca volvulus 0.028 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.028 1 1
Brugia malayi Dopamine receptor protein 1 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0177 0.5169 0.9349
Brugia malayi G-protein coupled receptor 0.028 1 1
Leishmania major cathepsin L-like protease 0.0072 0.0242 0.0438
Echinococcus multilocularis rhodopsin orphan GPCR 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.028 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.028 1 1
Schistosoma mansoni neuropeptide receptor 0.028 1 1
Onchocerca volvulus 0.028 1 1
Loa Loa (eye worm) cysteine protease 0.0072 0.0242 0.0242
Echinococcus granulosus rhodopsin orphan GPCR 0.028 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.028 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0242 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0177 0.5169 0.5049
Brugia malayi larval opioid receptor 0.028 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0185 0.5529 1
Brugia malayi hypothetical protein 0.028 1 1
Toxoplasma gondii cathepsin CPL 0.0072 0.0242 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni opsin-like receptor 0.028 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.028 1 1
Echinococcus multilocularis orexin receptor type 2 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Brugia malayi hypothetical protein 0.028 1 1
Echinococcus multilocularis somatostatin receptor 0.028 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni amine GPCR 0.028 1 1
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0177 0.5169 0.5169
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0177 0.5169 0.5169
Echinococcus multilocularis alpha 1A adrenergic receptor 0.028 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.028 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0185 0.5529 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.028 1 1
Giardia lamblia Cathepsin B precursor 0.0067 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.028 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0072 0.0242 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0072 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.028 1 1
Echinococcus multilocularis sex peptide receptor 0.028 1 1
Echinococcus multilocularis neuropeptide receptor 0.028 1 1
Echinococcus granulosus g-protein coupled receptor 0.028 1 1
Schistosoma mansoni biogenic amine receptor 0.028 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.028 1 1
Schistosoma mansoni hypothetical protein 0.028 1 1

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) = 4.5 ug ml-1 Inhibitory effect on the proliferation of human T-lymphocyte (MT-4) ChEMBL. 1324318
ID50 (functional) = 5.14 ug ml-1 Inhibitory effect on the proliferation of human T-lymphoblast cells (Molt-4F) ChEMBL. 1324318
ID50 (functional) = 17.4 ug ml-1 Inhibitory effect on the proliferation of murine leukemia cells (L1210) ChEMBL. 1324318
MCC (functional) > 10 ug ml-1 Evaluation in HeLa cell cultures for cytotoxicity that is to cause microscopically detectable alteration of normal cell morphology ChEMBL. 1324318
MIC (functional) > 8 ug ml-1 Compound was evaluated for antiviral activity against respiratory syncitial virus (long) in HeLa cell cultures(Concentration required to reduce virus-induced cytopathogenicity by 50%) ChEMBL. 1324318
MIC (functional) > 10 ug ml-1 Evaluation for antiviral activity against vesicular stomatitis virus in HeLa cell cultures(Concentration required to reduce virus-induced cytopathogenicity by 50%) ChEMBL. 1324318
MIC (functional) > 10 ug ml-1 Evaluation for antiviral activity against Coxsackie virus B4 in HeLa cell cultures(Concentration required to reduce virus-induced cytopathogenicity by 50%) ChEMBL. 1324318
MIC (functional) > 10 ug ml-1 Evaluation for antiviral activity against polio virus-1 in HeLa cell cultures(Concentration required to reduce virus-induced cytopathogenicity by 50%) ChEMBL. 1324318

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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