Detailed information for compound 1687263

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 499.536 | Formula: C24H25N3O7S
  • H donors: 3 H acceptors: 5 LogP: 2.06 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)N(c1ccc(cc1)N)c1ccccc1
  • InChi: 1S/C24H25N3O7S/c1-33-20-15-21(34-2)22(14-19(20)26-23(28)12-13-24(29)30)35(31,32)27(17-6-4-3-5-7-17)18-10-8-16(25)9-11-18/h3-11,14-15H,12-13,25H2,1-2H3,(H,26,28)(H,29,30)
  • InChiKey: LOWPPNMRMWEKTJ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU Get druggable targets OG5_131193 All targets in OG5_131193
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase Get druggable targets OG5_131193 All targets in OG5_131193
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU Get druggable targets OG5_131193 All targets in OG5_131193
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase Get druggable targets OG5_131193 All targets in OG5_131193

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus sex peptide receptor 0.0111 0.0494 0.0484
Brugia malayi G-protein coupled receptor 0.0111 0.0494 0.1344
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0684 0.3865 0.5
Schistosoma mansoni biogenic amine receptor 0.0111 0.0494 0.0478
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.3865 1
Brugia malayi follicle stimulating hormone receptor 0.0111 0.0494 0.1344
Echinococcus granulosus hypothetical protein 0.0111 0.0494 0.0484
Echinococcus granulosus muscleblind protein 0.0143 0.0681 0.0671
Echinococcus granulosus tar DNA binding protein 0.0063 0.0212 0.0202
Echinococcus granulosus g protein coupled receptor 0.0111 0.0494 0.0484
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus multilocularis g protein coupled receptor 0.0111 0.0494 0.0478
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0494 0.0478
Schistosoma mansoni opsin-like receptor 0.0111 0.0494 0.0478
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0494 0.0478
Schistosoma mansoni hypothetical protein 0.0111 0.0494 0.0478
Echinococcus multilocularis microtubule associated protein 2 0.0659 0.3715 0.3704
Loa Loa (eye worm) TYRA-2 protein 0.0111 0.0494 0.0494
Brugia malayi hypothetical protein 0.0111 0.0494 0.1344
Schistosoma mansoni hypothetical protein 0.0111 0.0494 0.0478
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.0581 0.102
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0111 0.0494 0.0494
Onchocerca volvulus 0.0111 0.0494 0.3953
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0109 0.0109
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0684 0.3865 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0494 0.0478
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0212 0.0212
Onchocerca volvulus Huntingtin homolog 0.0117 0.053 0.4259
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0285 0.0275
Mycobacterium ulcerans hypothetical protein 0.0125 0.0581 0.102
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0111 0.0494 0.0484
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus granulosus somatostatin receptor 0.0111 0.0494 0.0484
Schistosoma mansoni hypothetical protein 0.0338 0.1831 0.1818
Brugia malayi hypothetical protein 0.0111 0.0494 0.1344
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0212 0.0195
Echinococcus multilocularis geminin 0.0338 0.1831 0.1818
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0111 0.0494 0.0478
Brugia malayi RNA binding protein 0.0063 0.0212 0.0577
Brugia malayi Pre-SET motif family protein 0.0206 0.1055 0.2872
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Brugia malayi Tachykinin-like peptides receptor 99D 0.0111 0.0494 0.1344
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0111 0.0494 0.1344
Brugia malayi ORL1-like opioid receptor 0.0111 0.0494 0.1344
Brugia malayi G protein-coupled receptor F59B2.13 0.0111 0.0494 0.1344
Echinococcus multilocularis muscleblind protein 1 0.0143 0.0681 0.0665
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0109 0.0093
Echinococcus granulosus fmrfamide receptor 0.0111 0.0494 0.0484
Loa Loa (eye worm) hypothetical protein 0.0651 0.3672 0.3672
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0111 0.0494 0.0484
Echinococcus multilocularis fmrfamide receptor 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0109 0.0099
Schistosoma mansoni growth hormone secretagogue receptor 0.0111 0.0494 0.0478
Onchocerca volvulus 0.0111 0.0494 0.3953
Echinococcus granulosus alpha 1A adrenergic receptor 0.0111 0.0494 0.0484
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Brugia malayi RE15519p 0.0111 0.0494 0.1344
Schistosoma mansoni myosin xvIII 0.0111 0.0494 0.0478
Echinococcus granulosus neuropeptides capa receptor 0.0111 0.0494 0.0484
Plasmodium vivax SET domain protein, putative 0.003 0.0017 0.5
Schistosoma mansoni neuropeptide receptor 0.0111 0.0494 0.0478
Loa Loa (eye worm) RNA binding protein 0.0063 0.0212 0.0212
Onchocerca volvulus 0.0111 0.0494 0.3953
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Schistosoma mansoni biogenic amine (5HT) receptor 0.1728 1 1
Brugia malayi hypothetical protein 0.0111 0.0494 0.1344
Echinococcus granulosus neuropeptide receptor 0.0111 0.0494 0.0484
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0494 0.0484
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0111 0.0494 0.1344
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0494 0.0478
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0111 0.0494 0.0494
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0111 0.0494 0.0484
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0111 0.0494 0.1344
Schistosoma mansoni opsin-like receptor 0.0111 0.0494 0.0478
Echinococcus granulosus neuropeptide FF receptor 2 0.0111 0.0494 0.0484
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0111 0.0494 0.0478
Echinococcus granulosus 7TM GPCR rhodopsin 0.0111 0.0494 0.0484
Onchocerca volvulus 0.0111 0.0494 0.3953
Brugia malayi AKH receptor 0.0111 0.0494 0.1344
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0111 0.0494 0.0478
Echinococcus multilocularis dro:myosuppressin receptor 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Brugia malayi hypothetical protein 0.0111 0.0494 0.1344
Echinococcus granulosus tm gpcr rhodopsin 0.0111 0.0494 0.0484
Loa Loa (eye worm) hypothetical protein 0.0143 0.0681 0.0681
Schistosoma mansoni biogenic amine receptor 0.0111 0.0494 0.0478
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0109 0.0298
Loa Loa (eye worm) G-protein coupled receptor 0.0111 0.0494 0.0494
Onchocerca volvulus 0.0111 0.0494 0.3953
Echinococcus multilocularis neuropeptide s receptor 0.0111 0.0494 0.0478
Brugia malayi hypothetical protein 0.0111 0.0494 0.1344
Schistosoma mansoni microtubule-associated protein tau 0.0659 0.3715 0.3704
Schistosoma mansoni amine GPCR 0.0111 0.0494 0.0478
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0125 0.0581 0.102
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0207 0.0191
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0494 0.0478
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0494 0.0484
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0111 0.0494 0.0484
Echinococcus granulosus tachykinin peptides receptor 99D 0.0111 0.0494 0.0484
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0207 0.0191
Echinococcus granulosus orexin receptor type 2 0.0111 0.0494 0.0484
Schistosoma mansoni adenoreceptor 0.0111 0.0494 0.0478
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0111 0.0494 0.0478
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0111 0.0494 0.0478
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0111 0.0494 0.0478
Onchocerca volvulus 0.0111 0.0494 0.3953
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0109 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0212 0.0195
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus granulosus dro:myosuppressin receptor 0.0111 0.0494 0.0484
Onchocerca volvulus 0.0111 0.0494 0.3953
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0494 0.0478
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.0494 0.0478
Brugia malayi hypothetical protein 0.0111 0.0494 0.1344
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0494 0.0478
Echinococcus multilocularis allatostatin A receptor 0.0111 0.0494 0.0478
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Onchocerca volvulus 0.0111 0.0494 0.3953
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0111 0.0494 0.1344
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0212 0.0195
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.1728 1 1
Echinococcus granulosus allatostatin A receptor 0.0111 0.0494 0.0484
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0111 0.0494 0.1344
Echinococcus granulosus microtubule associated protein 2 0.0659 0.3715 0.3708
Loa Loa (eye worm) hypothetical protein 0.0117 0.053 0.053
Echinococcus multilocularis orexin receptor type 2 0.0111 0.0494 0.0478
Onchocerca volvulus 0.0111 0.0494 0.3953
Echinococcus granulosus g-protein coupled receptor 0.0111 0.0494 0.0484
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Brugia malayi hypothetical protein 0.0111 0.0494 0.1344
Echinococcus multilocularis somatostatin receptor 0.0111 0.0494 0.0478
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0125 0.0581 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0111 0.0494 0.0478
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0494 0.0478
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0017 0.0006
Brugia malayi hypothetical protein 0.0111 0.0494 0.1344
Onchocerca volvulus 0.0111 0.0494 0.3953
Echinococcus multilocularis neuropeptide Y receptor 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0143 0.0681 0.0681
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0111 0.0494 0.0484
Echinococcus granulosus neuropeptide receptor A26 0.0111 0.0494 0.0484
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0494 0.0484
Schistosoma mansoni hypothetical protein 0.0338 0.1831 0.1818
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0494 0.0478
Echinococcus multilocularis neuropeptide receptor A26 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0111 0.0494 0.0478
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0111 0.0494 0.0478
Echinococcus multilocularis neuropeptide Y receptor 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus granulosus neuropeptide Y receptor 0.0111 0.0494 0.0484
Brugia malayi G protein-coupled receptor 0.0111 0.0494 0.1344
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0111 0.0494 0.0494
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0684 0.3865 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0111 0.0494 0.0478
Leishmania major C-8 sterol isomerase-like protein 0.0651 0.3672 1
Brugia malayi putative neuropeptide receptor 0.0111 0.0494 0.1344
Onchocerca volvulus Neuropeptide F receptor homolog 0.0111 0.0494 0.3953
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0494 0.0484
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Schistosoma mansoni histamine h1 receptor 0.0111 0.0494 0.0478
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0109 0.0093
Schistosoma mansoni opsin-like receptor 0.0111 0.0494 0.0478
Echinococcus granulosus G protein coupled receptor 139 0.0111 0.0494 0.0484
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0109 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0494 0.0478
Schistosoma mansoni biogenic amine (5HT) receptor 0.0111 0.0494 0.0478
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0111 0.0494 0.0478
Onchocerca volvulus 0.0111 0.0494 0.3953
Echinococcus multilocularis G protein coupled receptor 139 0.0111 0.0494 0.0478
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0111 0.0494 0.0478
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0494 0.0484
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0111 0.0494 0.0478
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0111 0.0494 0.0478
Loa Loa (eye worm) G-protein coupled receptor 0.0111 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Onchocerca volvulus 0.0111 0.0494 0.3953
Brugia malayi hypothetical protein 0.0111 0.0494 0.1344
Echinococcus multilocularis fmrfamide receptor 0.0111 0.0494 0.0478
Onchocerca volvulus Huntingtin homolog 0.0117 0.053 0.4259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0494 0.0478
Echinococcus granulosus neuropeptide s receptor 0.0111 0.0494 0.0484
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0111 0.0494 0.0478
Treponema pallidum licC protein (licC) 0.0125 0.0581 0.5
Schistosoma mansoni hypothetical protein 0.0111 0.0494 0.0478
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Schistosoma mansoni hypothetical protein 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0111 0.0494 0.0478
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0212 0.0212
Schistosoma mansoni amine GPCR 0.0449 0.2482 0.2469
Brugia malayi Melatonin receptor type 1A 0.0111 0.0494 0.1344
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0651 0.3672 1
Schistosoma mansoni neuropeptide F-like receptor 0.0111 0.0494 0.0478
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0111 0.0494 0.0478
Schistosoma mansoni neuropeptide F-like receptor 0.0111 0.0494 0.0478
Brugia malayi Pre-SET motif family protein 0.003 0.0017 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0494 0.0478
Brugia malayi Serotonin receptor 0.0111 0.0494 0.1344
Brugia malayi neuropeptide F receptor 0.0111 0.0494 0.1344
Brugia malayi GnHR receptor homolog 0.0111 0.0494 0.1344
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0651 0.3672 0.5
Schistosoma mansoni biogenic amine receptor 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus multilocularis neuropeptide receptor 0.0111 0.0494 0.0478
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0111 0.0494 0.3953
Mycobacterium ulcerans hypothetical protein 0.0125 0.0581 0.102
Echinococcus multilocularis neuropeptide receptor 0.0111 0.0494 0.0478
Trypanosoma brucei C-8 sterol isomerase, putative 0.0651 0.3672 0.5
Schistosoma mansoni hypothetical protein 0.0053 0.0153 0.0137
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1222 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0111 0.0494 0.1344
Brugia malayi Serotonin receptor 0.0111 0.0494 0.1344
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0111 0.0494 0.0478
Echinococcus multilocularis g protein coupled receptor 0.0111 0.0494 0.0478
Echinococcus granulosus neuropeptide receptor 0.0111 0.0494 0.0484
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1055 0.1055
Loa Loa (eye worm) hypothetical protein 0.1728 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0111 0.0494 0.0478
Schistosoma mansoni neuropeptide receptor 0.0111 0.0494 0.0478
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0109 0.0093
Onchocerca volvulus 0.0111 0.0494 0.3953
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.0581 0.102
Loa Loa (eye worm) melatonin receptor type 1A 0.0111 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus multilocularis muscleblind protein 0.0143 0.0681 0.0665
Brugia malayi Dopamine receptor protein 1 0.0111 0.0494 0.1344
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Onchocerca volvulus 0.0111 0.0494 0.3953
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0494 0.0478
Echinococcus multilocularis sex peptide receptor 0.0111 0.0494 0.0478
Echinococcus granulosus 7tm_1 domain containing protein 0.0111 0.0494 0.0484
Loa Loa (eye worm) neuropeptide F receptor 0.0111 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Brugia malayi Muscleblind-like protein 0.0143 0.0681 0.1855
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0111 0.0494 0.0478
Brugia malayi hypothetical protein 0.0117 0.053 0.1444
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0212 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0494 0.0484
Loa Loa (eye worm) neuropeptide F receptor 0.0111 0.0494 0.0494
Echinococcus multilocularis neuropeptides capa receptor 0.0111 0.0494 0.0478
Echinococcus multilocularis neuropeptide FF receptor 2 0.0111 0.0494 0.0478
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0207 0.0191
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Schistosoma mansoni neuropeptide receptor 0.0111 0.0494 0.0478
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0494 0.0478
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0111 0.0494 0.0494
Echinococcus multilocularis neuropeptides capa receptor 0.0111 0.0494 0.0478
Brugia malayi larval opioid receptor 0.0111 0.0494 0.1344
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0207 0.3381
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0109 0.0093
Onchocerca volvulus 0.0111 0.0494 0.3953
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus granulosus geminin 0.0338 0.1831 0.1823
Echinococcus multilocularis g-protein coupled receptor 0.0111 0.0494 0.0478
Schistosoma mansoni alpha-1 adrenergic receptor 0.0111 0.0494 0.0478
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Brugia malayi G-protein coupled receptor 0.0111 0.0494 0.1344
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0111 0.0494 0.0478
Schistosoma mansoni neuropeptide f receptor 76f 0.0111 0.0494 0.0478
Onchocerca volvulus 0.0111 0.0494 0.3953
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus granulosus g protein coupled receptor 0.0111 0.0494 0.0484
Echinococcus granulosus tm gpcr rhodopsin 0.0111 0.0494 0.0484
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0111 0.0494 0.0478
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0111 0.0494 0.0484
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0494 0.0478
Brugia malayi Dopamine receptor protein 2 0.0111 0.0494 0.1344
Brugia malayi sulfakinin receptor protein 0.0111 0.0494 0.1344
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus granulosus biogenic amine 5HT receptor 0.0111 0.0494 0.0484
Echinococcus granulosus peptide allatostatin:somatostatin 0.0111 0.0494 0.0484
Echinococcus multilocularis serotonin receptor 0.1728 1 1
Brugia malayi Dopamine receptor 0.0111 0.0494 0.1344
Schistosoma mansoni amine GPCR 0.0111 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Schistosoma mansoni neuropeptide receptor 0.0111 0.0494 0.0478
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0207 0.0197
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0212 0.0577
Loa Loa (eye worm) hypothetical protein 0.0333 0.18 0.18
Loa Loa (eye worm) hypothetical protein 0.0117 0.053 0.053
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0111 0.0494 0.0478
Onchocerca volvulus 0.0235 0.1223 1
Schistosoma mansoni amine GPCR 0.0111 0.0494 0.0478
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0111 0.0494 0.0478
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0111 0.0494 0.0494
Echinococcus granulosus neuropeptides capa receptor 0.0111 0.0494 0.0484
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Brugia malayi neuropeptide F receptor 0.0111 0.0494 0.1344
Echinococcus granulosus tm gpcr rhodopsin 0.0111 0.0494 0.0484
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0212 0.0195
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0285 0.0269
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Echinococcus multilocularis g protein coupled receptor 0.0111 0.0494 0.0478
Echinococcus multilocularis serotonin receptor 0.1728 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0111 0.0494 0.0484
Schistosoma mansoni amine GPCR 0.0111 0.0494 0.0478
Echinococcus granulosus serotonin receptor 0.0111 0.0494 0.0484
Loa Loa (eye worm) hypothetical protein 0.003 0.0017 0.0017
Echinococcus granulosus g protein coupled receptor 0.0111 0.0494 0.0484
Echinococcus granulosus neuropeptide Y receptor 0.0111 0.0494 0.0484
Echinococcus multilocularis rhodopsin orphan GPCR 0.0111 0.0494 0.0478
Brugia malayi TAR-binding protein 0.0063 0.0212 0.0577
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0212 0.0195
Loa Loa (eye worm) hypothetical protein 0.0111 0.0494 0.0494
Brugia malayi hypothetical protein 0.0111 0.0494 0.1344
Onchocerca volvulus 0.0111 0.0494 0.3953

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.699 Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate ChEMBL. 25544688
IC50 (binding) = 0.02 uM Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate ChEMBL. 25544688

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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