Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 protease | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | Get druggable targets OG5_131408 | All targets in OG5_131408 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.8288 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.0297 | 1 |
Schistosoma mansoni | high-affinity choline transporter | 0.2115 | 0.2506 | 0.2293 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.022 | 0.5 |
Echinococcus granulosus | solute carrier family 5 | 0.8288 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2115 | 0.2506 | 1 |
Onchocerca volvulus | 0.2115 | 0.2506 | 1 | |
Leishmania major | mitochondrial DNA polymerase beta | 0.0296 | 0.0297 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.0108 | 0.3643 |
Schistosoma mansoni | sodium/solute symporter | 0.2115 | 0.2506 | 0.2293 |
Schistosoma mansoni | inositol transporter | 0.8288 | 1 | 1 |
Brugia malayi | GH02984p | 0.2115 | 0.2506 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.2115 | 0.2506 | 0.5 |
Brugia malayi | Sodium:solute symporter family protein | 0.2115 | 0.2506 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0156 | 0.0127 | 0.5 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1528 | 0.1793 | 0.156 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.8288 | 1 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.8288 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.8288 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.0297 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.0127 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2115 | 0.2506 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0296 | 0.0297 | 1 |
Schistosoma mansoni | inositol transporter | 0.8288 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.8288 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -6.91 | Inhibition of human immunodeficiency virus type 1 (HIV-1) protease enzyme. | ChEMBL. | 11087569 |
IC50 (binding) | = 6.914 | Inhibitory activity against HIV-1 protease. | ChEMBL. | 10956210 |
Log IC50 (binding) | = 6.914 | Inhibitory activity against HIV-1 protease. | ChEMBL. | 10956210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.