Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus multilocularis | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus granulosus | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma mansoni | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Abnormal catecholamine distribution protein 1 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | 532 aa | 504 aa | 34.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0558 | 0.9176 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.3502 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.3502 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 0.3502 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 0.3502 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 0.3502 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 0.3502 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0087 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0601 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 19 nM | Displacement of [3H]vesamicol from human VAChT expressed in rat PC12 cells after 24 hrs by liquid scintillation counting | ChEMBL. | 22739089 |
Ki (binding) | = 34000 nM | Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig membrane after 90 mins by liquid scintillation counting | ChEMBL. | 22739089 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.