Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neprilysin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | Neprilysin | 750 aa | 778 aa | 20.2 % |
Onchocerca volvulus | Neprilysin | 750 aa | 713 aa | 34.1 % | |
Onchocerca volvulus | Neprilysin | 750 aa | 682 aa | 31.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0327 | 0.0327 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0504 | 0.6744 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0504 | 0.6744 | 0.6744 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0154 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0154 | 0.0327 | 0.0327 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0681 | 1 | 1 |
Onchocerca volvulus | 0.0544 | 0.749 | 0.749 | |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0154 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0154 | 0.0327 | 0.0327 |
Echinococcus multilocularis | fibrillin 1 | 0.0154 | 0.0327 | 0.0486 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0504 | 0.6744 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0504 | 0.6744 | 0.6744 |
Echinococcus granulosus | laminin | 0.0154 | 0.0327 | 0.0486 |
Leishmania major | hypothetical protein, conserved | 0.0504 | 0.6744 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0504 | 0.6744 | 0.6744 |
Echinococcus multilocularis | laminin | 0.0154 | 0.0327 | 0.0486 |
Echinococcus granulosus | Tolloid protein 1 | 0.0154 | 0.0327 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0504 | 0.6744 | 0.6744 |
Onchocerca volvulus | Arrow homolog | 0.0154 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0327 | 0.0327 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0504 | 0.6744 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0681 | 1 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0154 | 0.0327 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.0681 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0154 | 0.0327 | 0.0327 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0154 | 0.0327 | 0.0327 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0504 | 0.6744 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0504 | 0.6744 | 1 |
Onchocerca volvulus | 0.0504 | 0.6744 | 0.6744 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0681 | 1 | 1 |
Onchocerca volvulus | 0.0681 | 1 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.0154 | 0.0327 | 0.0327 |
Brugia malayi | Protein kinase domain containing protein | 0.0504 | 0.6744 | 0.6744 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0504 | 0.6744 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0154 | 0.0327 | 0.0327 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.