Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0712 | 0.0803 | 0.0803 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4914 | 0.6343 | 1 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0113 | 0.0014 | 0.0014 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.7689 | 1 | 1 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0712 | 0.0803 | 0.0803 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0113 | 0.0014 | 0.0014 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0528 | 0.0561 | 0.0864 |
Wolbachia endosymbiont of Brugia malayi | isoleucyl-tRNA synthetase | 0.0113 | 0.0014 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.7689 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.7689 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0712 | 0.0803 | 0.0803 |
Toxoplasma gondii | isoleucyl-tRNA synthetase family protein | 0.0113 | 0.0014 | 0.0022 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.111 | 0.1328 | 0.0813 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4914 | 0.6343 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.111 | 0.1328 | 0.1328 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0712 | 0.0803 | 0.0803 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4914 | 0.6343 | 1 |
Brugia malayi | thymidylate synthase | 0.111 | 0.1328 | 0.1328 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.111 | 0.1328 | 0.1328 |
Giardia lamblia | Isoleucyl-tRNA synthetase | 0.0113 | 0.0014 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.111 | 0.1328 | 0.1316 |
Mycobacterium ulcerans | thymidylate synthase | 0.111 | 0.1328 | 0.1316 |
Brugia malayi | hypothetical protein | 0.0528 | 0.0561 | 0.0561 |
Echinococcus multilocularis | dihydrofolate reductase | 0.7689 | 1 | 1 |
Loa Loa (eye worm) | isoleucyl-tRNA synthetase | 0.0113 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0712 | 0.0803 | 0.0803 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.4914 | 0.6343 | 1 |
Brugia malayi | isoleucyl-tRNA synthetase family protein | 0.0113 | 0.0014 | 0.0014 |
Schistosoma mansoni | dihydrofolate reductase | 0.7689 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.111 | 0.1328 | 0.1328 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.7689 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0712 | 0.0803 | 0.0803 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0712 | 0.0803 | 0.0803 |
Onchocerca volvulus | 0.111 | 0.1328 | 1 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4914 | 0.6343 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.7689 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4914 | 0.6343 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.7689 | 1 | 1 |
Echinococcus granulosus | isoleucyl tRNA synthetase, cytoplasmic | 0.0113 | 0.0014 | 0.0014 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0528 | 0.0561 | 1 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, cytoplasmic | 0.0113 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | thymidylate synthase | 0.111 | 0.1328 | 0.1328 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.7689 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0014 | 0.0014 |
Entamoeba histolytica | isoleucyl-tRNA synthetase, putative | 0.0113 | 0.0014 | 0.5 |
Treponema pallidum | isoleucyl-tRNA synthetase | 0.0113 | 0.0014 | 0.5 |
Brugia malayi | isoleucyl-tRNA synthetase | 0.0113 | 0.0014 | 0.0014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log RA (functional) | = -0.24 | Antimalarial activity of the compound was determined against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum W-2 clone | ChEMBL. | 11784134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.