Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0714 | 0.6615 | 0.8989 |
Onchocerca volvulus | 0.0876 | 0.8685 | 1 | |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0618 | 0.5402 | 0.609 |
Echinococcus granulosus | aminopeptidase N | 0.0876 | 0.8685 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1238 | 0.0331 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0276 | 0.1032 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0386 | 0.2435 | 0.2557 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.2435 | 0.2259 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0276 | 0.1032 | 0.5 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0386 | 0.2435 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.06 | 0.5172 | 0.6667 |
Brugia malayi | Peptidase family M1 containing protein | 0.0276 | 0.1032 | 0.0886 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1152 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.2435 | 0.2259 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.033 | 0.1731 | 0.1125 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0386 | 0.2435 | 0.1833 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0276 | 0.1032 | 0.4239 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0276 | 0.1032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1152 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.0763 | 0.7242 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1238 | 0.0331 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0276 | 0.1032 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.033 | 0.1731 | 0.0913 |
Brugia malayi | Peptidase family M13 containing protein | 0.0386 | 0.2435 | 0.2557 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0276 | 0.1032 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0876 | 0.8685 | 0.8533 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0276 | 0.1032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1152 | 0.0193 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.033 | 0.1731 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1238 | 0.0331 |
Brugia malayi | Peptidase family M1 containing protein | 0.0876 | 0.8685 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0276 | 0.1032 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0276 | 0.1032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1238 | 0.0331 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0276 | 0.1032 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0386 | 0.2435 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0386 | 0.2435 | 0.1564 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1238 | 0.0331 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0386 | 0.2435 | 1 |
Brugia malayi | hypothetical protein | 0.0276 | 0.1032 | 0.0886 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0276 | 0.1032 | 0.5 |
Toxoplasma gondii | peptidase family M13 protein | 0.0386 | 0.2435 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1238 | 0.0331 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.033 | 0.1731 | 0.7107 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0618 | 0.5402 | 0.7037 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0386 | 0.2435 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0285 | 0.1152 | 0.0193 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0276 | 0.1032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1152 | 0.0193 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0276 | 0.1032 | 0.4239 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.2435 | 0.2259 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0285 | 0.1152 | 0.0193 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.