Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin beta 2 | 0.0685 | 0.4099 | 0.9857 |
Schistosoma mansoni | integrin alpha | 0.0903 | 0.5918 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0405 | 0.1759 | 0.4231 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.014 | 0.014 |
Echinococcus granulosus | integrin alpha ps | 0.0405 | 0.1759 | 0.4231 |
Echinococcus granulosus | integrin alpha 3 | 0.0692 | 0.4159 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0211 | 0.014 | 0.0236 |
Echinococcus granulosus | integrin beta 2 | 0.0685 | 0.4099 | 0.9857 |
Echinococcus multilocularis | integrin alpha ps | 0.0405 | 0.1759 | 0.4231 |
Schistosoma mansoni | integrin alpha-ps | 0.0405 | 0.1759 | 0.2973 |
Loa Loa (eye worm) | hypothetical protein | 0.0683 | 0.4082 | 0.4082 |
Schistosoma mansoni | integrin beta subunit | 0.0545 | 0.2926 | 0.4944 |
Loa Loa (eye worm) | hypothetical protein | 0.0498 | 0.2539 | 0.2539 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0925 | 0.61 | 1 |
Echinococcus multilocularis | integrin alpha 3 | 0.0692 | 0.4159 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0903 | 0.5918 | 0.9099 |
Loa Loa (eye worm) | integrin beta-2 | 0.0925 | 0.61 | 0.61 |
Loa Loa (eye worm) | hypothetical protein | 0.0709 | 0.4298 | 0.4298 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.4662 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.