Detailed information for compound 1704806

Basic information

Technical information
  • TDR Targets ID: 1704806
  • Name: N-[2-(1-cyclohexenyl)ethyl]-2-[4-(2,4-dichlor ophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl] acetamide
  • MW: 424.321 | Formula: C20H23Cl2N3O3
  • H donors: 2 H acceptors: 3 LogP: 3.67 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1C(=O)NC(C1=O)(C)c1ccc(cc1Cl)Cl)NCCC1=CCCCC1
  • InChi: 1S/C20H23Cl2N3O3/c1-20(15-8-7-14(21)11-16(15)22)18(27)25(19(28)24-20)12-17(26)23-10-9-13-5-3-2-4-6-13/h5,7-8,11H,2-4,6,9-10,12H2,1H3,(H,23,26)(H,24,28)
  • InChiKey: DIOKBFXRIOLATC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(1-cyclohexenyl)ethyl]-2-[4-(2,4-dichlorophenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]acetamide
  • N-[2-(1-cyclohexenyl)ethyl]-2-[4-(2,4-dichlorophenyl)-4-methyl-2,5-dioxo-1-imidazolidinyl]acetamide
  • N-[2-(1-cyclohexenyl)ethyl]-2-[4-(2,4-dichlorophenyl)-2,5-diketo-4-methyl-imidazolidin-1-yl]acetamide
  • N-[2-(1-cyclohexenyl)ethyl]-2-[4-(2,4-dichlorophenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]ethanamide
  • T5411872

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi FAD binding domain containing protein 0.0318 0.5684 0.5684
Plasmodium vivax flavodoxin domain containing protein 0.0456 0.8717 0.8717
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0058 0 0.5
Plasmodium vivax hypothetical protein, conserved 0.0197 0.3033 0.3033
Echinococcus granulosus biogenic amine 5HT receptor 0.0148 0.1968 0.1968
Echinococcus granulosus methionine synthase reductase 0.0318 0.5684 0.5684
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0456 0.8717 0.8159
Brugia malayi flavodoxin family protein 0.0197 0.3033 0.3033
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0514 1 1
Echinococcus multilocularis serotonin receptor 0.0148 0.1968 0.1968
Loa Loa (eye worm) FAD binding domain-containing protein 0.0318 0.5684 0.5684
Giardia lamblia Nitric oxide synthase, inducible 0.0456 0.8717 1
Chlamydia trachomatis sulfite reductase 0.0318 0.5684 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0514 1 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0514 1 1
Entamoeba histolytica type A flavoprotein, putative 0.0197 0.3033 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0148 0.1968 0.1968
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0197 0.3033 0.3033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0038 0.0038
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0197 0.3033 0.3033
Loa Loa (eye worm) flavodoxin family protein 0.0197 0.3033 0.3033
Trichomonas vaginalis sulfite reductase, putative 0.0514 1 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.0514 1 1
Toxoplasma gondii flavodoxin domain-containing protein 0.0255 0.4316 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0038 0.0038
Echinococcus multilocularis methionine synthase reductase 0.0318 0.5684 0.5684
Loa Loa (eye worm) hypothetical protein 0.0416 0.7835 0.7835
Trypanosoma cruzi p450 reductase, putative 0.0514 1 1
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0514 1 1
Giardia lamblia Hypothetical protein 0.0456 0.8717 1
Mycobacterium tuberculosis Possible oxygenase 0.0058 0 0.5
Trypanosoma brucei C-8 sterol isomerase, putative 0.0416 0.7835 0.7835
Toxoplasma gondii flavodoxin domain-containing protein 0.0255 0.4316 1
Leishmania major C-8 sterol isomerase-like protein 0.0416 0.7835 0.7835
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0038 0.0038
Mycobacterium tuberculosis Probable oxidoreductase 0.0058 0 0.5
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0514 1 1
Leishmania major cytochrome P450 reductase, putative 0.0456 0.8717 0.8717
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0514 1 1
Onchocerca volvulus 0.0058 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0212 0.3378 0.3378
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0058 0 0.5
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0514 1 1
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0514 1 1
Entamoeba histolytica type A flavoprotein, putative 0.0197 0.3033 0.5
Mycobacterium tuberculosis Probable monooxygenase 0.0058 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0148 0.1968 0.1968
Treponema pallidum flavodoxin 0.0197 0.3033 1
Plasmodium falciparum nitric oxide synthase, putative 0.0514 1 1
Entamoeba histolytica type A flavoprotein, putative 0.0197 0.3033 0.5
Loa Loa (eye worm) hypothetical protein 0.0514 1 1
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0197 0.3033 0.3033
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0514 1 1
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0197 0.3033 0.3033
Schistosoma mansoni NADPH flavin oxidoreductase 0.0259 0.4402 0.4402
Leishmania major hypothetical protein, conserved 0.0197 0.3033 0.3033
Loa Loa (eye worm) hypothetical protein 0.006 0.0038 0.0038
Entamoeba histolytica type A flavoprotein, putative 0.0197 0.3033 0.5
Entamoeba histolytica type A flavoprotein, putative 0.0197 0.3033 0.5
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0514 1 1
Schistosoma mansoni diflavin oxidoreductase 0.0255 0.4316 0.4316
Brugia malayi FAD binding domain containing protein 0.0514 1 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0514 1 1
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0197 0.3033 0.3033
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0197 0.3033 0.3033
Schistosoma mansoni cytochrome P450 reductase 0.0514 1 1
Leishmania major p450 reductase, putative 0.0514 1 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0416 0.7835 0.7835
Loa Loa (eye worm) hypothetical protein 0.0148 0.1968 0.1968
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0514 1 1
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0318 0.5684 0.5684
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0514 1 1
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0514 1 1
Echinococcus multilocularis serotonin receptor 0.0148 0.1968 0.1968
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0416 0.7835 0.7835

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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