Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.01 | 1 | 1 |
Leishmania major | thymidylate kinase-like protein | 0.0087 | 0.8037 | 0.8037 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.01 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 1 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.0087 | 0.8037 | 0.5 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.01 | 1 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.01 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.01 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.01 | 1 | 1 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.01 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.01 | 1 | 1 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0087 | 0.8037 | 0.5 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0087 | 0.8037 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.01 | 1 | 1 |
Mycobacterium ulcerans | thymidylate kinase | 0.0087 | 0.8037 | 0.5 |
Echinococcus granulosus | protein kinase shaggy | 0.01 | 1 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0087 | 0.8037 | 0.8037 |
Giardia lamblia | Kinase, CMGC GSK | 0.01 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0087 | 0.8037 | 0.5 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.01 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.01 | 1 | 1 |
Echinococcus multilocularis | protein kinase shaggy | 0.01 | 1 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.01 | 1 | 1 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.01 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.01 | 1 | 1 |
Onchocerca volvulus | 0.01 | 1 | 1 | |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0087 | 0.8037 | 0.8037 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.01 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0087 | 0.8037 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0 % | Activity of Escherichia coli thymidine phosphorylase assessed as drug phosphorylation after 2 hrs | ChEMBL. | 18272369 |
Activity (binding) | = 0 % | Activity of Escherichia coli thymidine phosphorylase assessed as drug phosphorylation after 1 hr | ChEMBL. | 18272369 |
Ki (binding) | = 7 uM | Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis | ChEMBL. | 12941330 |
Ki (binding) | = 7 uM | Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis | ChEMBL. | 12941330 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.