TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 495.566 | Formula: C26H26FN3O4S
H donors: 2 H acceptors: 5 LogP: 3.71 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCc1ccc2c(c1)c(Cc1ccncc1)c(n2CCNS(=O)(=O)c1ccc(cc1)F)C
InChi: 1S/C26H26FN3O4S/c1-18-23(16-20-10-12-28-13-11-20)24-17-19(3-9-26(31)32)2-8-25(24)30(18)15-14-29-35(33,34)22-6-4-21(27)5-7-22/h2,4-8,10-13,17,29H,3,9,14-16H2,1H3,(H,31,32)
InChiKey: QXOWCKXRNBDYFR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Thromboxane A2 receptor	Starlite/ChEMBL	No references
Homo sapiens	thromboxane A synthase 1 (platelet)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	opsin-like receptor	Thromboxane A2 receptor	341 aa	313 aa	22.4 %
Trypanosoma brucei	cytochrome P450, putative	thromboxane A synthase 1 (platelet)	534 aa	498 aa	21.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Melatonin receptor type 1A	0.0024	0.0546	0.0546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Brugia malayi	hypothetical protein	0.0024	0.0546	0.0546
Schistosoma mansoni	amine GPCR	0.0024	0.0546	0.0546
Echinococcus granulosus	hypothetical protein	0.0024	0.0546	0.2132
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0546	0.2132
Schistosoma mansoni	amine GPCR	0.0024	0.0546	0.0546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0546	0.0546
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0024	0.0546	0.2132
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0024	0.0546	0.2132
Brugia malayi	G protein-coupled receptor F59B2.13	0.0024	0.0546	0.0546
Brugia malayi	Dopamine receptor	0.0024	0.0546	0.0546
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	g-protein coupled receptor	0.0024	0.0546	0.2132
Schistosoma mansoni	growth hormone secretagogue receptor	0.0024	0.0546	0.0546
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0024	0.0546	0.0546
Brugia malayi	GnHR receptor homolog	0.0024	0.0546	0.0546
Echinococcus multilocularis	G protein coupled receptor 139	0.0024	0.0546	0.2132
Echinococcus granulosus	neuropeptide receptor A26	0.0024	0.0546	0.2132
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0035	0.2563	0.2563
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0546	0.0546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0546	0.0546
Brugia malayi	neuropeptide F receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	sex peptide receptor	0.0024	0.0546	0.2132
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0024	0.0546	0.0546
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0024	0.0546	0.0546
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0024	0.0546	0.2132
Leishmania major	endonuclease G, putative	0.0021	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0546	0.2132
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0035	0.2563	0.2563
Brugia malayi	hypothetical protein	0.0024	0.0546	0.0546
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0546	0.2132
Schistosoma mansoni	opsin-like receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	dro:myosuppressin receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0024	0.0546	0.2132
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0035	0.2563	1
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0076	1	1
Brugia malayi	sulfakinin receptor protein	0.0024	0.0546	0.0546
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0546	0.2132
Trypanosoma cruzi	endonuclease G, putative	0.0021	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0546	0.2132
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0035	0.2563	0.2563
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0024	0.0546	0.0546
Onchocerca volvulus		0.0035	0.2563	0.2133
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0546	0.2132
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0546	0.2132
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0035	0.2563	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0024	0.0546	0.0546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Schistosoma mansoni	opsin-like receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0546	0.2132
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0035	0.2563	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.1553	0.1065
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0024	0.0546	0.0546
Brugia malayi	Serotonin receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0035	0.2563	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0546	0.0546
Schistosoma mansoni	myosin xvIII	0.0024	0.0546	0.0546
Echinococcus multilocularis	ectonucleotide	0.003	0.1553	0.6061
Echinococcus granulosus	neuropeptide s receptor	0.0024	0.0546	0.2132
Brugia malayi	hypothetical protein	0.0024	0.0546	0.0546
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0024	0.0546	0.2132
Trypanosoma cruzi	endonuclease G, putative	0.0021	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0546	0.0546
Schistosoma mansoni	hypothetical protein	0.0024	0.0546	0.0546
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0546	0.2132
Schistosoma mansoni	neuropeptide F-like receptor	0.0024	0.0546	0.0546
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0021	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0546	0.0546
Trypanosoma brucei	endonuclease G, putative	0.0021	0	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0024	0.0546	0.0546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0546	0.0546
Brugia malayi	hypothetical protein	0.0024	0.0546	0.0546
Schistosoma mansoni	amine GPCR	0.0024	0.0546	0.0546
Echinococcus granulosus	neuropeptide FF receptor 2	0.0024	0.0546	0.2132
Trypanosoma brucei	endonuclease G, putative	0.0021	0	0.5
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0035	0.2563	1
Onchocerca volvulus		0.0076	1	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0035	0.2563	1
Brugia malayi	AKH receptor	0.0024	0.0546	0.0546
Brugia malayi	hypothetical protein	0.0024	0.0546	0.0546
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0024	0.0546	0.0546
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0035	0.2563	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0024	0.0546	0.2132
Brugia malayi	G protein-coupled receptor	0.0024	0.0546	0.0546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0546	0.0546
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0024	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0035	0.2563	0.2133
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0024	0.0546	0.2132
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0035	0.2563	1
Echinococcus granulosus	fmrfamide receptor	0.0024	0.0546	0.2132
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0546	0.2132
Echinococcus granulosus	somatostatin receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0546	0.2132
Schistosoma mansoni	amine GPCR	0.0024	0.0546	0.0546
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0546	0.2132
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0546	0.2132
Brugia malayi	follicle stimulating hormone receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0546	0.2132
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0035	0.2563	1
Echinococcus granulosus	G protein coupled receptor 139	0.0024	0.0546	0.2132
Echinococcus multilocularis	neuropeptide s receptor	0.0024	0.0546	0.2132
Schistosoma mansoni	hypothetical protein	0.0076	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0024	0.0546	0.0546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0546	0.0546
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0024	0.0546	0.0546
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0546	0.2132
Echinococcus granulosus	g-protein coupled receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0024	0.0546	0.2132
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0024	0.0546	0.2132
Brugia malayi	G-protein coupled receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0546	0.2132
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	7tm_1 domain containing protein	0.0024	0.0546	0.2132
Schistosoma mansoni	hypothetical protein	0.0024	0.0546	0.0546
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	allatostatin A receptor	0.0024	0.0546	0.2132
Brugia malayi	Serotonin receptor	0.0024	0.0546	0.0546
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.003	0.1553	0.6061
Echinococcus multilocularis	serotonin receptor	0.0024	0.0546	0.2132
Onchocerca volvulus		0.0035	0.2563	0.2133
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0546	0.2132
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0035	0.2563	1
Echinococcus multilocularis	sex peptide receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	neuropeptide receptor A26	0.0024	0.0546	0.2132
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0546	0.2132
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0546	0.2132
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0546	0.0546
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0546	0.0546
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0035	0.2563	0.2563
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0546	0.2132
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0024	0.0546	0.0546
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0024	0.0546	0.0546
Schistosoma mansoni	hypothetical protein	0.0024	0.0546	0.0546
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0024	0.0546	0.0546
Brugia malayi	Dopamine receptor protein 1	0.0024	0.0546	0.0546
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0546	0.0546
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0035	0.2563	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0024	0.0546	0.0546
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0546	0.2132
Brugia malayi	hypothetical protein	0.0024	0.0546	0.0546
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0024	0.0546	0.2132
Brugia malayi	hypothetical protein	0.0024	0.0546	0.0546
Brugia malayi	larval opioid receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.003	0.1553	0.6061
Schistosoma mansoni	adenoreceptor	0.0024	0.0546	0.0546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0024	0.0546	0.0546
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0546	0.2132
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0021	0	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0024	0.0546	0.2132
Echinococcus granulosus	orexin receptor type 2	0.0024	0.0546	0.2132
Schistosoma mansoni	neuropeptide f receptor 76f	0.0024	0.0546	0.0546
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0546	0.2132
Brugia malayi	hypothetical protein	0.0024	0.0546	0.0546
Brugia malayi	putative neuropeptide receptor	0.0024	0.0546	0.0546
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0546	0.2132
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0024	0.0546	0.0546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0546	0.2132
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0035	0.2563	0.2563
Echinococcus multilocularis	somatostatin receptor	0.0024	0.0546	0.2132
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0021	0	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0024	0.0546	0.0546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Loa Loa (eye worm)	hypothetical protein	0.0035	0.2563	0.2133
Brugia malayi	G-protein coupled receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0546	0.2132
Echinococcus granulosus	serotonin receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0024	0.0546	0.2132
Brugia malayi	neuropeptide F receptor	0.0024	0.0546	0.0546
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0021	0	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0024	0.0546	0.2132
Brugia malayi	RE15519p	0.0024	0.0546	0.0546
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0546	0.0546
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	serotonin receptor	0.0024	0.0546	0.2132
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0546	0.2132
Brugia malayi	ORL1-like opioid receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	allatostatin A receptor	0.0024	0.0546	0.2132
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0546	0.2132
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0035	0.2563	0.2133
Schistosoma mansoni	amine GPCR	0.0024	0.0546	0.0546
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0546	0.2132
Echinococcus granulosus	7TM GPCR rhodopsin	0.0024	0.0546	0.2132
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0546	0.0546
Echinococcus granulosus	ectonucleotide	0.003	0.1553	0.6061
Schistosoma mansoni	hypothetical protein	0.0024	0.0546	0.0546
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0024	0.0546	0.2132
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0024	0.0546	0.0546
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0024	0.0546	0.2132
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Schistosoma mansoni	opsin-like receptor	0.0024	0.0546	0.0546
Brugia malayi	hypothetical protein	0.0024	0.0546	0.0546
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0546	0.0546
Brugia malayi	Dopamine receptor protein 2	0.0024	0.0546	0.0546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Schistosoma mansoni	histamine h1 receptor	0.0024	0.0546	0.0546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0546	0.2132
Brugia malayi	hypothetical protein	0.0024	0.0546	0.0546
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0024	0.0546	0.2132
Trypanosoma brucei	endonuclease G, putative	0.0021	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.078 uM	Compound was tested for the ability to inhibit human platelets microsomal Thromboxane A2 synthase	ChEMBL.	No reference
IC50 (binding)	= 0.078 uM	Compound was tested for the ability to inhibit human platelets microsomal Thromboxane A2 synthase	ChEMBL.	No reference
Kd (functional)	= 10.13	Compound was tested in vitro for Thromboxane A2 receptor antagonism by inhibiting contraction of rat aorta induced by the stable thromboxane agonist U-46,619	ChEMBL.	No reference
pA2 (functional)	= 10.13	Compound was tested in vitro for Thromboxane A2 receptor antagonism by inhibiting contraction of rat aorta induced by the stable thromboxane agonist U-46,619	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL102533

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 170720