Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peter pan protein homolog | 0.0068 | 1 | 0.5 |
Schistosoma mansoni | peter pan-related | 0.0068 | 1 | 0.5 |
Leishmania major | peter pan protein, putative | 0.0068 | 1 | 0.5 |
Schistosoma mansoni | peter pan-related | 0.0068 | 1 | 0.5 |
Trypanosoma cruzi | peter pan protein, putative | 0.0068 | 1 | 0.5 |
Echinococcus multilocularis | peter pan | 0.0068 | 1 | 1 |
Echinococcus granulosus | peter pan | 0.0068 | 1 | 1 |
Trichomonas vaginalis | ssf, putative | 0.0068 | 1 | 0.5 |
Giardia lamblia | Peter pan protein | 0.0068 | 1 | 0.5 |
Loa Loa (eye worm) | brix domain-containing protein | 0.0068 | 1 | 0.5 |
Toxoplasma gondii | brix domain-containing protein | 0.0068 | 1 | 0.5 |
Trypanosoma brucei | brix domain containing protein, putative | 0.0068 | 1 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0068 | 1 | 0.5 |
Trypanosoma cruzi | peter pan protein, putative | 0.0068 | 1 | 0.5 |
Plasmodium falciparum | BRIX domain, putative | 0.0068 | 1 | 0.5 |
Entamoeba histolytica | brix domain containing protein | 0.0068 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.