Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | platelet-derived growth factor receptor, beta polypeptide | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0011 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0147 | 1 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0011 | 0.0334 | 0.0334 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0537 | 0.0537 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0594 | 0.0594 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0011 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0594 | 0.0594 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0334 | 0.0334 |
Echinococcus granulosus | defective proboscis extension response | 0.0011 | 0.0334 | 0.0334 |
Schistosoma mansoni | rotamase | 0.0147 | 1 | 1 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0537 | 0.0537 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0144 | 0.9754 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0016 | 0.0666 | 0.0666 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0011 | 0.0334 | 0.0334 |
Trichomonas vaginalis | rotamase, putative | 0.0147 | 1 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0011 | 0.0334 | 0.0334 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0797 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0334 | 0.0334 |
Echinococcus multilocularis | Immunoglobulin | 0.0011 | 0.0334 | 0.0334 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.0045 | 0.2718 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0144 | 0.9754 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0797 | 0.0797 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0144 | 0.9754 | 1 |
Echinococcus granulosus | expressed protein | 0.0147 | 1 | 1 |
Echinococcus multilocularis | expressed protein | 0.0147 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0147 | 1 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0011 | 0.0334 | 0.0334 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0334 | 0.0334 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0144 | 0.9754 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0797 | 0.0797 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0537 | 0.0537 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0797 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0334 | 0.0334 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0537 | 0.0537 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0144 | 0.9754 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0016 | 0.0666 | 0.0666 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0144 | 0.9754 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0334 | 0.0334 |
Echinococcus multilocularis | Immunoglobulin | 0.0011 | 0.0334 | 0.0334 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0594 | 0.0594 |
Echinococcus granulosus | Immunoglobulin | 0.0011 | 0.0334 | 0.0334 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.19 uM l-1 | Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells | ChEMBL. | 12086491 |
IC50 (binding) | = 0.74 uM l-1 | Inhibition of Platelet-derived growth factor receptor beta phosphorylation | ChEMBL. | 12086491 |
IC50 (binding) | = 0.74 uM l-1 | Inhibition of Platelet-derived growth factor receptor beta phosphorylation | ChEMBL. | 12086491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.