Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hypothetical protein | 0.0677 | 0.7387 | 1 |
Brugia malayi | Serotonin receptor | 0.0454 | 0.4879 | 0.5025 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0884 | 0.971 | 1 |
Onchocerca volvulus | 0.0077 | 0.0651 | 0.0579 | |
Echinococcus granulosus | zinc finger protein 541 | 0.0026 | 0.0076 | 0.0103 |
Echinococcus multilocularis | zinc finger protein 541 | 0.0026 | 0.0076 | 0.0104 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0462 | 0.0462 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0462 | 0.0462 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0584 | 0.0584 |
Schistosoma mansoni | rest corepressor (corest) protein | 0.0026 | 0.0076 | 0.1303 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0248 | 0.0256 |
Echinococcus granulosus | SANT DNA binding | 0.0026 | 0.0076 | 0.0103 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0071 | 0.0584 | 0.0798 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0076 | 0.0076 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.002 | 0.0016 | 0.0016 |
Schistosoma mansoni | rest corepressor (corest) protein | 0.0026 | 0.0076 | 0.1303 |
Echinococcus multilocularis | conserved hypothetical protein | 0.067 | 0.7309 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0076 | 0.0076 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0248 | 0.4254 |
Echinococcus granulosus | metastasis associated protein MTA1 | 0.0026 | 0.0076 | 0.0103 |
Echinococcus multilocularis | rest corepressor (corest) protein | 0.0026 | 0.0076 | 0.0104 |
Echinococcus multilocularis | metastasis associated protein 1 (mta1) | 0.0026 | 0.0076 | 0.0104 |
Echinococcus granulosus | REST corepressor 3 | 0.0026 | 0.0076 | 0.0103 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0026 | 0.0076 | 0.0078 |
Schistosoma mansoni | metastasis-associated protein 1 (mta1) | 0.0026 | 0.0076 | 0.1303 |
Echinococcus granulosus | metastasis associated protein 1 mta1 | 0.0026 | 0.0076 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0884 | 0.971 | 0.971 |
Echinococcus granulosus | mesoderm induction early response protein 1 | 0.0026 | 0.0076 | 0.0103 |
Onchocerca volvulus | CoRest homolog | 0.091 | 1 | 1 |
Brugia malayi | ELM2 domain containing protein | 0.0026 | 0.0076 | 0.0078 |
Echinococcus multilocularis | metastasis associated protein MTA1 | 0.0026 | 0.0076 | 0.0104 |
Schistosoma mansoni | zinc finger protein | 0.0026 | 0.0076 | 0.1306 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0248 | 0.0248 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0462 | 0.0476 |
Plasmodium vivax | hypothetical protein | 0.0026 | 0.0076 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0584 | 0.0584 |
Echinococcus multilocularis | mesoderm induction early response protein 1 | 0.0026 | 0.0076 | 0.0104 |
Brugia malayi | ELM2 domain containing protein | 0.0026 | 0.0076 | 0.0078 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0071 | 0.0584 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0077 | 0.0651 | 0.067 |
Loa Loa (eye worm) | GATA zinc finger family protein | 0.0026 | 0.0076 | 0.0076 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0462 | 0.0476 |
Echinococcus multilocularis | SANT, DNA binding | 0.0026 | 0.0076 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0016 | 0.0016 |
Schistosoma mansoni | metastasis-associated protein 1 (mta1) | 0.0026 | 0.0076 | 0.1303 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0071 | 0.0584 | 0.079 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0076 | 0.0076 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.