Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 478 aa | 20.7 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 420 aa | 19.8 % | |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 467 aa | 25.1 % | |
Loa Loa (eye worm) | TYRA-2 protein | Adrenergic receptor alpha-2 | 450 aa | 488 aa | 23.8 % |
Echinococcus multilocularis | fmrfamide receptor | Adrenergic receptor alpha-2 | 450 aa | 366 aa | 19.9 % |
Echinococcus multilocularis | neuropeptides capa receptor | Adrenergic receptor alpha-2 | 450 aa | 486 aa | 20.6 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Adrenergic receptor alpha-2 | 450 aa | 423 aa | 31.7 % |
Echinococcus multilocularis | serotonin receptor | Adrenergic receptor alpha-2 | 450 aa | 426 aa | 31.9 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Adrenergic receptor alpha-2 | 450 aa | 433 aa | 27.9 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Adrenergic receptor alpha-2 | 450 aa | 473 aa | 24.1 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 476 aa | 21.0 % |
Schistosoma mansoni | amine GPCR | Adrenergic receptor alpha-2 | 450 aa | 439 aa | 29.2 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Adrenergic receptor alpha-2 | 450 aa | 378 aa | 20.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jun-related protein | 0.007 | 0.0148 | 0.0148 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.3715 | 1 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.3715 | 1 | 1 |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.3715 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0148 | 0.0148 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.3715 | 1 | 1 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.3715 | 1 | 0.5 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0075 | 0.0163 | 0.0163 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.3715 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0059 | 0.0059 |
Mycobacterium ulcerans | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.129 | 0.3446 | 0.5 |
Onchocerca volvulus | 0.0067 | 0.0142 | 0.5 | |
Echinococcus multilocularis | jun protein | 0.0086 | 0.0191 | 0.0191 |
Entamoeba histolytica | hypothetical protein | 0.129 | 0.3446 | 0.3407 |
Entamoeba histolytica | hypothetical protein | 0.2425 | 0.6514 | 0.6494 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, putative | 0.129 | 0.3446 | 0.3407 |
Brugia malayi | bZIP transcription factor family protein | 0.0086 | 0.0191 | 0.0133 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0142 | 0.0083 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.3715 | 1 | 0.5 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0075 | 0.0163 | 0.0163 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.3715 | 1 | 1 |
Echinococcus granulosus | jun protein | 0.0086 | 0.0191 | 0.0191 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0059 | 0.0059 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.3715 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0086 | 0.0191 | 0.0191 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.3715 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.3715 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0086 | 0.0191 | 0.0191 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.3715 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0185 | 0.0185 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.3715 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.3715 | 1 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.3715 | 1 | 1 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.3715 | 1 | 1 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.3715 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0059 | 0.0059 |
Mycobacterium leprae | PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) | 0.129 | 0.3446 | 0.5 |
Trichomonas vaginalis | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.3715 | 1 | 0.5 |
Entamoeba histolytica | deoxycytidine triphosphate deaminase, putative | 0.129 | 0.3446 | 0.3407 |
Entamoeba histolytica | hypothetical protein | 0.2425 | 0.6514 | 0.6494 |
Entamoeba histolytica | hypothetical protein | 0.3715 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0059 | 0.0059 |
Mycobacterium ulcerans | deoxycytidine triphosphate deaminase | 0.129 | 0.3446 | 0.5 |
Mycobacterium tuberculosis | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) | 0.129 | 0.3446 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 165 nM | Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain using 0.2 nM [3H]-rauwolscine as radioligand | ChEMBL. | 8709134 |
Ki (binding) | = 165 nM | Alpha-2 adrenergic receptor binding affinity was tested against membrane preparations of rat brain using 0.2 nM [3H]-rauwolscine as radioligand | ChEMBL. | 8709134 |
Ki (binding) | = 574 nM | Alpha-1 adrenergic receptor binding affinity in rat brain membranes | ChEMBL. | 8709134 |
Ki (binding) | = 574 nM | Alpha-1 adrenergic receptor binding affinity in rat brain membranes | ChEMBL. | 8709134 |
Ratio (binding) | = 3.48 | Selectivity ratio of Ki of alpha-1 adrenergic receptor to alpha-2 receptor | ChEMBL. | 8709134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.