Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetyltransferase | 0.0145 | 0.4158 | 0.4158 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.0779 | 0.0779 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.1096 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0052 | 0.1096 | 0.009 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0145 | 0.4158 | 0.4158 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1359 | 0.1359 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1015 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0882 | 0.0882 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.1096 | 0.009 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0882 | 0.0882 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1015 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0322 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1015 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0023 | 0.0145 | 0.0145 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0882 | 0.0882 |
Brugia malayi | hypothetical protein | 0.0131 | 0.3702 | 0.3702 |
Onchocerca volvulus | Huntingtin homolog | 0.0131 | 0.3702 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.1015 | 0.1015 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1359 | 0.1359 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0023 | 0.0145 | 0.0145 |
Onchocerca volvulus | Huntingtin homolog | 0.0131 | 0.3702 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0145 | 0.4158 | 0.4158 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.1015 | 0.1015 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.1015 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.3702 | 0.3702 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0145 | 0.0145 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0145 | 0.4158 | 0.4158 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.073 | 0.073 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0485 | 0.0485 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0882 | 0.0882 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.1015 | 0.1015 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0322 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0052 | 0.1096 | 0.1096 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0882 | 0.0882 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.1015 | 0.0257 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0143 | 0.4106 | 0.3688 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0882 | 0.0882 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1359 | 0.1359 |
Loa Loa (eye worm) | Poly(ADP-ribose) glycohydrolase | 0.0322 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0882 | 0.0882 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.1096 | 1 |
Trypanosoma brucei | poly(ADP-ribose) glycohydrolase, putative | 0.0322 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0141 | 0.4023 | 0.4023 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.3702 | 0.3702 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.1015 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.1015 | 0.1015 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0882 | 0.0882 |
Leishmania major | hypothetical protein, conserved | 0.0052 | 0.1096 | 1 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0322 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1359 | 0.1359 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0052 | 0.1096 | 0.0344 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.1015 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0322 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0052 | 0.1096 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.1015 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.073 | 0.073 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.1096 | 0.009 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.1015 | 0.1015 |
Schistosoma mansoni | poly(ADP-ribose) glycohydrolase | 0.0322 | 1 | 1 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0143 | 0.4106 | 0.3608 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.4106 | 0.3688 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1096 | 0.1096 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0322 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0882 | 0.0882 |
Echinococcus multilocularis | poly(ADP ribose) glycohydrolase | 0.0322 | 1 | 1 |
Echinococcus granulosus | polyADP ribose glycohydrolase | 0.0322 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.073 | 0.073 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.