Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis | 4'-phosphopantetheinyl transferase ffp | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 198 aa | 28.3 % |
Trichomonas vaginalis | conserved hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 197 aa | 22.3 % |
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Onchocerca volvulus | 4'-phosphopantetheinyl transferase ffp | 224 aa | 186 aa | 26.3 % | |
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.01 | 0.6845 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0028 | 0.0831 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1767 | 0.2581 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0766 | 0.899 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0766 | 0.0766 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.4591 | 0.4591 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0766 | 0.899 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0028 | 0.0831 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0766 | 0.899 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0187 | 0.0187 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0.0831 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.6845 | 0.6845 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0028 | 0.0831 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1767 | 0.1767 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4591 | 0.6708 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 1 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.01 | 0.6845 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0187 | 0.0187 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0766 | 0.899 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0831 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0766 | 0.9118 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4591 | 0.6708 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4591 | 0.6708 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0028 | 0.0831 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0766 | 0.0766 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.4591 | 0.4591 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0831 | 0.5 |
Onchocerca volvulus | 0.01 | 0.6845 | 1 | |
Brugia malayi | TAR-binding protein | 0.0073 | 0.4591 | 0.4591 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0028 | 0.0831 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0187 | 0.1267 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.3289 | 0.3289 |
Brugia malayi | RNA binding protein | 0.0073 | 0.4591 | 0.4591 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0766 | 0.899 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.4591 | 0.4591 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0766 | 0.899 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4591 | 0.6708 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0831 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0766 | 0.899 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0187 | 0.0187 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0766 | 0.899 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.3289 | 0.3289 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.01 | 0.6845 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.3289 | 0.3289 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.4591 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4591 | 0.6708 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0028 | 0.0831 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0028 | 0.0831 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0187 | 0.0187 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0766 | 0.0766 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0028 | 0.0831 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.4591 | 0.6708 |
Mycobacterium leprae | conserved hypothetical protein | 0.0028 | 0.0831 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0766 | 0.9118 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0766 | 0.0766 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.4591 | 0.6708 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0028 | 0.0831 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0766 | 0.0766 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0766 | 0.0766 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.01 | 0.6845 | 0.6845 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0187 | 0.0187 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.8489 uM | PubChem BioAssay. Gel-Based Assay for Inhibitos of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase): Chemistry Optimization Follow up. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. Gel-Based Assay for Inhibitos of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase): Chemistry Optimization Follow up. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 21.5227 uM | PubChem BioAssay. Extended Characterization of HPGD Inhibitors: Counterscreen Against HSD17b4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.