Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | tubulin beta chain, putative | 0.0022 | 0.2558 | 1 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Schistosoma mansoni | tubulin subunit alpha | 0.0022 | 0.2558 | 0.2277 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Brugia malayi | tubulin alpha-2 chain | 0.0022 | 0.2558 | 0.2277 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0012 | 0.0363 | 0.0363 |
Echinococcus granulosus | tubulin alpha chain | 0.0022 | 0.2558 | 0.2277 |
Schistosoma mansoni | alpha tubulin | 0.0022 | 0.2558 | 0.2277 |
Trypanosoma brucei | alpha tubulin | 0.0022 | 0.2558 | 1 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0015 | 0.1111 | 0.3406 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Plasmodium falciparum | alpha tubulin 1 | 0.0022 | 0.2558 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0022 | 0.2558 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0022 | 0.2558 | 0.2277 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0022 | 0.2558 | 0.2277 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0016 | 0.1447 | 0.494 |
Schistosoma mansoni | alpha tubulin | 0.0022 | 0.2558 | 0.2277 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1111 | 0.1111 |
Trypanosoma brucei | alpha tubulin | 0.0022 | 0.2558 | 1 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0022 | 0.2558 | 0.2277 |
Echinococcus multilocularis | tubulin alpha chain | 0.0022 | 0.2558 | 0.2277 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0022 | 0.2558 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0022 | 0.2558 | 0.2277 |
Loa Loa (eye worm) | alpha-tubulin | 0.0022 | 0.2558 | 0.2558 |
Brugia malayi | Tubulin alpha-2 chain | 0.0022 | 0.2558 | 0.2277 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0022 | 0.2558 | 0.2558 |
Brugia malayi | Tubulin alpha chain | 0.0022 | 0.2558 | 0.2277 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0022 | 0.2558 | 1 |
Plasmodium falciparum | alpha tubulin 2 | 0.0022 | 0.2558 | 1 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0022 | 0.2558 | 0.2277 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0022 | 0.2558 | 0.2277 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0022 | 0.2558 | 0.2277 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0015 | 0.1111 | 0.1111 |
Brugia malayi | Tubulin alpha-2 chain | 0.0022 | 0.2558 | 0.2277 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0022 | 0.2558 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0022 | 0.2558 | 0.2277 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0022 | 0.2558 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 1 | 1 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0022 | 0.2558 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0022 | 0.2558 | 1 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0022 | 0.2558 | 0.2277 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0022 | 0.2558 | 1 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0022 | 0.2558 | 1 |
Loa Loa (eye worm) | alpha-tubulin | 0.0022 | 0.2558 | 0.2558 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Giardia lamblia | Alpha-tubulin | 0.0022 | 0.2558 | 1 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0016 | 0.1447 | 0.1447 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0022 | 0.2558 | 0.2277 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0022 | 0.2558 | 0.2277 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0016 | 0.1447 | 0.1447 |
Brugia malayi | alpha-tubulin | 0.0022 | 0.2558 | 0.2277 |
Giardia lamblia | Alpha-tubulin | 0.0022 | 0.2558 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0012 | 0.0363 | 0.0363 |
Echinococcus multilocularis | tubulin alpha chain | 0.0022 | 0.2558 | 0.2277 |
Echinococcus granulosus | alpha tubulin | 0.0022 | 0.2558 | 0.2277 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0022 | 0.2558 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0022 | 0.2558 | 0.2277 |
Loa Loa (eye worm) | BEN-1 protein | 0.0012 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | beta-tubulin | 0.0012 | 0.0363 | 0.0363 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0022 | 0.2558 | 0.2277 |
Schistosoma mansoni | alpha tubulin | 0.0022 | 0.2558 | 0.2277 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0022 | 0.2558 | 1 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0012 | 0.0363 | 0.0363 |
Echinococcus multilocularis | tubulin alpha chain | 0.0022 | 0.2558 | 0.2277 |
Brugia malayi | tubulin alpha chain - mouse | 0.0022 | 0.2558 | 0.2277 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0022 | 0.2558 | 0.2277 |
Loa Loa (eye worm) | tubulin beta chain | 0.0012 | 0.0363 | 0.0363 |
Echinococcus granulosus | tubulin subunit TubB | 0.0022 | 0.2558 | 0.2277 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0022 | 0.2558 | 0.2277 |
Trypanosoma brucei | alpha tubulin | 0.0022 | 0.2558 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1447 | 0.1447 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2558 | 0.2558 |
Schistosoma mansoni | tubulin subunit alpha | 0.0022 | 0.2558 | 0.2277 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0022 | 0.2558 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0022 | 0.2558 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0022 | 0.2558 | 1 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0022 | 0.2558 | 0.2277 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0022 | 0.2558 | 0.2277 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0022 | 0.2558 | 0.2277 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0022 | 0.2558 | 0.2277 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0016 | 0.1447 | 0.1447 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0022 | 0.2558 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0022 | 0.2558 | 0.2277 |
Schistosoma mansoni | tubulin subunit alpha | 0.0022 | 0.2558 | 0.2277 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0022 | 0.2558 | 0.2277 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0022 | 0.2558 | 0.2558 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0022 | 0.2558 | 1 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0022 | 0.2558 | 0.2277 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0012 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0022 | 0.2558 | 0.2558 |
Echinococcus granulosus | tubulin alpha chain | 0.0022 | 0.2558 | 0.2277 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0012 | 0.0363 | 0.0363 |
Leishmania major | alpha tubulin | 0.0022 | 0.2558 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0022 | 0.2558 | 0.2277 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.